The PI3K/mTOR dual inhibitor NVP‐BEZ235 stimulates mutant p53 degradation to exert anti‐tumor effects on triple‐negative breast cancer cells
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DOI: 10.1002/2211-5463.12806
Abstract: Nearly half of human cancers harbor p53 mutations, and mutant p53 (mutp53) promotes carcinogenesis, metastasis, tumor recurrence and chemoresistance. mutp53 is observed in 30% of breast carcinomas, including triple‐negative breast cancer (TNBC), and thus mutp53… read more here.
Keywords: degradation; bez235; tnbc; mutant p53 ... See more keywords
Crizotinib Nanomicelles Synergize with Chemotherapy through Inducing Proteasomal Degradation of Mutp53 Proteins.
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DOI: 10.1021/acsami.2c18020
Abstract: TP53 missense mutations that express highly stabilized mutant p53 protein (mutp53) driving tumorigenesis have been witnessed in a considerable percentage of human cancers. The attempt to induce degradation of mutp53 has thus been an attractive… read more here.
Keywords: crizotinib nanomicelles; degradation mutp53; mutp53; proteasomal degradation ... See more keywords
Polo-like kinase 1 inhibitor onvansertib synergizes with paclitaxel in breast cancer carrying p53 mutation
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DOI: 10.1093/annonc/mdz242.044
Abstract: Abstract Background Somatic mutation in TP53 gene (mutp53) is a strong prognostic marker in breast cancer. Triple negative breast cancer (TNBC) is characterized by up to 80% mutp53 and the greatest overall genomic instability among… read more here.
Keywords: breast; breast cancer; polo like; mutp53 ... See more keywords
STAT3 and mutp53 Engage a Positive Feedback Loop Involving HSP90 and the Mevalonate Pathway
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DOI: 10.3389/fonc.2020.01102
Abstract: Oncosuppressor TP53 and oncogene STAT3 have been shown to engage an interplay in which they negatively influence each other. Conversely, mutant (mut) p53 may sustain STAT3 phosphorylation by displacing SH2 phosphatase while whether STAT3 could… read more here.
Keywords: mutp53; mevalonate pathway; stat3; hsp90 mevalonate ... See more keywords
Interplay between Endoplasmic Reticulum (ER) Stress and Autophagy Induces Mutant p53H273 Degradation
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DOI: 10.3390/biom10030392
Abstract: The unfolded protein response (UPR) is an adaptive response to intrinsic and external stressors, and it is mainly activated by the accumulation of misfolded proteins at the endoplasmic reticulum (ER) lumen producing ER stress. The… read more here.
Keywords: degradation; endoplasmic reticulum; stress; autophagy ... See more keywords
PBA Preferentially Impairs Cell Survival of Glioblastomas Carrying mutp53 by Reducing Its Expression Level, Stabilizing wtp53, Downregulating the Mevalonate Kinase and Dysregulating UPR
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DOI: 10.3390/biom10040586
Abstract: Phenylbutyrate (PBA) is a derivative of Butyric Acid (BA), which has the characteristics of being a histone deacetylase (HDAC) inhibitor and acting as a chemical chaperone. It has the potential to counteract a variety of… read more here.
Keywords: expression level; mevalonate kinase; pba; mutp53 ... See more keywords
Mutant p53 Depletion by Novel Inhibitors for HSP40/J-Domain Proteins Derived from the Natural Compound Plumbagin
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DOI: 10.3390/cancers14174187
Abstract: Simple Summary The tumor suppressor p53 is frequently mutated in human cancer. Accumulation of missense mutant p53 (mutp53) in tumors is crucial for malignant progression, and cancers are often addicted to oncogenic mutp53. However, strategies… read more here.
Keywords: compound; mutant p53; mutp53; domain ... See more keywords