LAUSR

Mutual Antagonism of Hypoxia-Inducible Factor Isoforms in Cardiac, Vascular, and Renal Disorders

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0 Published in 2020 at "JACC: Basic to Translational Science"

DOI: 10.1016/j.jacbts.2020.05.006

Abstract: Highlights • HIF-1α and HIF-2α promote cellular adaptation to acute hypoxia, but during prolonged activation, these isoforms exert mutually antagonistic effects on the redox state and on proinflammatory pathways.• Imbalances in HIF-1α and HIF-2α may… read more here.

Keywords: renal disorders; cardiac vascular; mutual antagonism; antagonism hypoxia ... See more keywords