Discovery of SI 1/20 and SI 1/22 as Mutual Prodrugs of 5‐Fluorouracil and Imidazole‐Based Heme Oxygenase 1 Inhibitor with Improved Cytotoxicity in DU145 Prostate Cancer Cells
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DOI: 10.1002/cmdc.202300047
Abstract: In this work, we extend the concept of 5‐fluorouracil/heme oxygenase 1 (5‐FU/HO‐1) inhibitor hybrid as an effective strategy for enhancing 5‐FU‐based anticancer therapies. For this purpose, we designed and synthesized new mutual prodrugs, named SI… read more here.
Keywords: imidazole based; oxygenase inhibitor; mutual prodrugs; heme oxygenase ... See more keywords
Mutual Prodrugs - Codrugs.
Sign Up to like & getrecommendations! Published in 2022 at "Current medicinal chemistry"
DOI: 10.2174/0929867330666221209102650
Abstract: This review encapsulates an extensive variety of substances identified as mutual prodrugs or codrugs, wherein two, or sometimes three, biologically active moieties are linked using an assortment of metabolically unstable bridging entities. Following the administration… read more here.
Keywords: chemistry; prodrugs codrugs; mutual prodrugs;