Declining detection rates for APC and biallelic MUTYH variants in polyposis patients, implications for DNA testing policy
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DOI: 10.1038/s41431-019-0509-z
Abstract: This study aimed to determine the prevalence of APC-associated familial adenomatous polyposis (FAP) and MUTYH-associated polyposis (MAP) in a large cohort, taking into account factors as adenoma count and year of diagnosis. All application forms… read more here.
Keywords: mutyh; biallelic mutyh; apc biallelic; detection rates ... See more keywords
MUTYH is associated with hepatocarcinogenesis in a non-alcoholic steatohepatitis mouse model
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DOI: 10.1038/s41598-021-83138-8
Abstract: Non-alcoholic steatohepatitis (NASH)-related HCC is associated with oxidative stress. However, the mechanisms underlying the development of NASH-related HCC is unclear. MUTYH is one of the enzymes that is involved in repair of oxidative DNA damage.… read more here.
Keywords: mutyh; non alcoholic; developed liver; alcoholic steatohepatitis ... See more keywords
Structure of the mammalian adenine DNA glycosylase MUTYH: insights into the base excision repair pathway and cancer
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DOI: 10.1093/nar/gkab492
Abstract: Abstract Mammalian MutY homologue (MUTYH) is an adenine DNA glycosylase that excises adenine inserted opposite 8-oxoguanine (8-oxoG). The inherited variations in human MUTYH gene are known to cause MUTYH-associated polyposis (MAP), which is associated with… read more here.
Keywords: mutyh; base excision; dna; dna glycosylase ... See more keywords
Abstract 4655: Association of a new germline variant in the MUTYH DNA glycosylase gene with colorectal adenoma transformation into malignancy
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DOI: 10.1158/1538-7445.am2019-4655
Abstract: Background: Germline mutations in mutY homolog (E.coli) (MUTYH)DNA glycosylase gene have been associated with recessive inheritance of multiple s adenoma. Several studies revealed that germline mutations in this gene are ethnicity related. This study aimed… read more here.
Keywords: germline; dna; mutyh; gene ... See more keywords
Association of base excision repair pathway genes OGG1, XRCC1 and MUTYH polymorphisms and the level of 8-oxo-guanine with increased risk of colorectal cancer occurrence.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of occupational medicine and environmental health"
DOI: 10.13075/ijomeh.1896.01901
Abstract: OBJECTIVES Reduced efficiency of DNA repair systems has long been a suspected factor in increasing the risk of cancer. In this work authors investigate influence of selected polymorphisms of DNA repair genes (XRCC1, OGG1 and… read more here.
Keywords: xrcc1; mutyh; risk; colorectal cancer ... See more keywords
New germline mutations in BRCA1, ATM, MUTYH, and RAD51D genes in Tuvans early-onset breast cancer patients.
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DOI: 10.32471/exp-oncology.2312-8852.vol-43-no-1.15587
Abstract: BACKGROUND In Russia, more than 50,000 women are diagnosed with breast cancer (BC) every year. Russia is a multinational country - about 200 ethnic groups live on its territory. Khakass, Buryats, Tuvans and other ethnic groups show higher… read more here.
Keywords: mutyh; breast cancer; early onset; rad51d ... See more keywords
Downregulation of MUTYH contributes to cisplatin‑resistance of esophageal squamous cell carcinoma cells by promoting Twist‑mediated EMT.
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DOI: 10.3892/or.2019.7347
Abstract: Acquired resistance to cisplatin (CDDP) in esophageal squamous cell carcinoma (ESCC) remains a major challenge in cancer therapy. Although progress has been made in identifying the mechanisms responsible for resistance to CDDP, the underlying mechanisms… read more here.
Keywords: mutyh; cddp; resistance; downregulation ... See more keywords