Purification of biomevalonate from fermentation broth and conversion of biomevalonate into biomevalonolactone.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of biotechnology"
DOI: 10.1016/j.jbiotec.2017.08.017
Abstract: Mevalonate (MVA) is a key compound of living organisms including bacteria, plants, and humans. MVA and mevalonolactone (MVL), a lactonized form of MVA, are important for pharmaceutical, cosmeceutical, and biotechnological applications. Although (R, S)-MVA with… read more here.
Keywords: purification biomevalonate; biomevalonate; fermentation; enantiomeric purity ... See more keywords
High titer mevalonate fermentation and its feeding as a building block for isoprenoids (isoprene and sabinene) production in engineered Escherichia coli
Sign Up to like & getrecommendations! Published in 2017 at "Process Biochemistry"
DOI: 10.1016/j.procbio.2017.07.021
Abstract: Abstract Isoprenoids are important fine chemicals as material monomers, advanced fuels and pharmaceuticals. A variety of natural isoprenoids can be synthesized by engineered microbial strains. This work established a process by dividing the current isoprenoid… read more here.
Keywords: production; sabinene; fermentation; process ... See more keywords
Optimising T cell (re)boosting strategies for adenoviral and modified vaccinia Ankara vaccine regimens in humans
Sign Up to like & getrecommendations! Published in 2020 at "NPJ Vaccines"
DOI: 10.1038/s41541-020-00240-0
Abstract: Simian adenoviral and modified vaccinia Ankara (MVA) viral vectors used in heterologous prime-boost strategies are potent inducers of T cells against encoded antigens and are in advanced testing as vaccine carriers for a wide range… read more here.
Keywords: mva nsmut; modified vaccinia; vaccinia ankara; mva ... See more keywords
MVA vector expression of SARS-CoV-2 spike protein and protection of adult Syrian hamsters against SARS-CoV-2 challenge
Sign Up to like & getrecommendations! Published in 2021 at "npj Vaccines"
DOI: 10.1038/s41541-021-00410-8
Abstract: Numerous vaccine candidates against SARS-CoV-2, the causative agent of the COVID-19 pandemic, are under development. The majority of vaccine candidates to date are designed to induce immune responses against the viral spike (S) protein, although… read more here.
Keywords: sars cov; mva; adult syrian; syrian hamsters ... See more keywords
Ebola virus – prospects for a novel virus-like-particle-expressing modified vaccinia Ankara-based vaccine
Sign Up to like & getrecommendations! Published in 2018 at "Expert Review of Vaccines"
DOI: 10.1080/14760584.2018.1510775
Abstract: The Ebola virus (EBOV) epidemic in West Africa that devastated Guinea, Liberia, and Sierra Leone from 2013 to 2016 became a global public health crisis and claimed over 11,000 human lives [1]. There were no… read more here.
Keywords: vaccinia; ebov; mva; vaccine ... See more keywords
Smartcoil—design, assembly and test of a 10 MVA superconducting air coil fault current limiter
Sign Up to like & getrecommendations! Published in 2019 at "Superconductor Science and Technology"
DOI: 10.1088/1361-6668/ab099a
Abstract: Within a German government funded project the partners Siemens AG and KIT have developed an iron-free inductive current limiter. The project aimed at a device for the medium voltage range, i.e. U = 10 kV… read more here.
Keywords: reactor coil; test; current limiter; mva ... See more keywords
P207 A proposal for individually tailored rituximab treatment based on clinical and B-cell biomarkers for remission maintenance in ANCA associated vasculitis
Sign Up to like & getrecommendations! Published in 2021 at "Rheumatology"
DOI: 10.1093/rheumatology/keab247.202
Abstract: Background/Aims Time-to-relapse after rituximab for ANCA vasculitis is variable and optimal retreatment strategy is unclear. We previously showed that repopulation of naïve B-cells at 6 months predicts sustained response. Our objective was to evaluate clinical… read more here.
Keywords: repopulation; relapse; mva; cell ... See more keywords
Novel Modified Vaccinia Virus Ankara Vector Expressing Anti-apoptotic Gene B13R Delays Apoptosis and Enhances Humoral Responses
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Virology"
DOI: 10.1128/jvi.01648-18
Abstract: MVA is an attractive viral vector for vaccine development due to its safety and immunogenicity in multiple species and humans even under conditions of immunodeficiency. Here, to further improve the immunogenicity of MVA, we developed… read more here.
Keywords: vector; b13r; apoptosis; mva ... See more keywords
Response to: 'Size of the shadow'
Sign Up to like & getrecommendations! Published in 2021 at "Heart"
DOI: 10.1136/heartjnl-2020-318919
Abstract: The Authors' reply We thank Dr Garbi and colleagues for their interest in our recently published study. The authors underline that mitral annular disjunction (MAD) cannot be considered a risk factor for sudden cardiac death… read more here.
Keywords: mad; size shadow; response size; cardiac imaging ... See more keywords
Vector Aided Microenvironment programming (VAMP): reprogramming the TME with MVA virus expressing IL-12 for effective antitumor activity
Sign Up to like & getrecommendations! Published in 2023 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2023-006718
Abstract: Background Tumor microenvironment (TME) represents a critical hurdle in cancer immunotherapy, given its ability to suppress antitumor immunity. Several efforts are made to overcome this hostile TME with the development of new therapeutic strategies modifying… read more here.
Keywords: antitumor; tme; antitumor activity; mva ... See more keywords
Late Administration of a Palladium Lipoic Acid Complex (POLY-MVA) Modifies Cardiac Mitochondria but Not Functional or Structural Manifestations of Radiation-Induced Heart Disease in a Rat Model
Sign Up to like & getrecommendations! Published in 2017 at "Radiation Research"
DOI: 10.1667/rr14643.1
Abstract: Exposure of the heart to ionizing radiation can cause adverse myocardial remodeling. In small animal models, local heart irradiation causes persistent alterations in cardiac mitochondrial function and swelling. POLY-MVA is a dietary supplement that contains… read more here.
Keywords: heart; poly mva; palladium lipoic; mva ... See more keywords