The potency of mitochondria enlargement for mitochondria-mediated terpenoid production in yeast
Sign Up to like & getrecommendations! Published in 2024 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-023-12922-5
Abstract: Abstract Terpenoids are widely used in the food, beverage, cosmetics, and pharmaceutical industries. Microorganisms have been extensively studied for terpenoid production. In yeast, the introduction of the mevalonate (MVA) pathway in organelles in addition to… read more here.
Keywords: terpenoid production; mitochondrial volume; mitochondria; mva pathway ... See more keywords
Transcriptional Tuning of Mevalonate Pathway Enzymes to Identify the Impact on Limonene Production in Escherichia coli
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c00483
Abstract: Heterologous production of limonene in microorganisms through the mevalonate (MVA) pathway has traditionally imposed metabolic burden and reduced cell fitness, where imbalanced stoichiometries among sequential enzymes result in the accumulation of toxic intermediates. Although prior… read more here.
Keywords: mva pathway; escherichia coli; limonene; production ... See more keywords
Mevalonate pathway inhibition reduces bladder cancer metastasis by modulating RhoB protein stability and integrin β1 localization
Sign Up to like & getrecommendations! Published in 2024 at "Communications Biology"
DOI: 10.1038/s42003-024-07067-8
Abstract: The progression and outcome of bladder cancer (BLCA) are critically affected by the propensity of tumor metastasis. Our previous study revealed that activation of the mevalonate (MVA) pathway promoted migration of BLCA cells; however, the… read more here.
Keywords: blca; protein stability; bladder cancer; metastasis ... See more keywords
Transcriptomic profiling reveals MEP pathway contributing to ginsenoside biosynthesis in Panax ginseng
Sign Up to like & getrecommendations! Published in 2019 at "BMC Genomics"
DOI: 10.1186/s12864-019-5718-x
Abstract: BackgroundPanax ginseng C. A. Mey is one of famous medicinal herb plant species. Its major bioactive compounds are various ginsenosides in roots and rhizomes. It is commonly accepted that ginsenosides are synthesized from terpene precursors,… read more here.
Keywords: ginseng; mep pathway; mva pathway; ginsenoside biosynthesis ... See more keywords
Synthesis of cembratriene-ol and cembratriene-diol in yeast via the MVA pathway
Sign Up to like & getrecommendations! Published in 2021 at "Microbial Cell Factories"
DOI: 10.1186/s12934-021-01523-4
Abstract: Background Cembranoids are one kind of diterpenoids with multiple biological activities. The tobacco cembratriene-ol (CBT-ol) and cembratriene-diol (CBT-diol) have high anti-insect and anti-fungal activities, which is attracting great attentions for their potential usage in sustainable… read more here.
Keywords: cembratriene; mva pathway; diol; cbt ... See more keywords
Biosynthesis of Isoprene Units in Euphorbia lathyris Laticifers vs. Other Tissues: MVA and MEP Pathways, Compartmentation and Putative Endophytic Fungi Contribution
Sign Up to like & getrecommendations! Published in 2019 at "Molecules"
DOI: 10.3390/molecules24234322
Abstract: Euphorbia species are characterized by a net of laticifers producing large amounts of triterpenes. These hydrocarbon-like metabolites can be converted into fuel by the methods of the oil industry. Euphorbia lathyris is easily grown at… read more here.
Keywords: biosynthesis isoprene; mva pathway; contribution; latex triterpenes ... See more keywords