Polypharmacology Approaches against the Pseudomonas aeruginosa MvfR Regulon and Their Application in Blocking Virulence and Antibiotic Tolerance.
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DOI: 10.1021/acschembio.6b01139
Abstract: Pseudomonas aeruginosa is an important nosocomial pathogen that is frequently recalcitrant to available antibiotics, underlining the urgent need for alternative therapeutic options against this pathogen. Targeting virulence functions is a promising alternative strategy as it… read more here.
Keywords: mvfr; pseudomonas aeruginosa; polypharmacology; mvfr regulon ... See more keywords
Molecular Insights into Function and Competitive Inhibition of Pseudomonas aeruginosa Multiple Virulence Factor Regulator
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DOI: 10.1128/mbio.02158-17
Abstract: ABSTRACT New approaches to antimicrobial drug discovery are urgently needed to combat intractable infections caused by multidrug-resistant (MDR) bacteria. Multiple virulence factor regulator (MvfR or PqsR), a Pseudomonas aeruginosa quorum sensing transcription factor, regulates functions… read more here.
Keywords: mvfr; pseudomonas aeruginosa; acute persistent; insights function ... See more keywords
MvfR Controls Tolerance to Polymyxin B by Regulating rfaD in Pseudomonas aeruginosa
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DOI: 10.1128/spectrum.00426-23
Abstract: Antibiotic resistance imposes a considerable challenge for the treatment of P. aeruginosa infections. Polymyxins are the last-resort antibiotics for the treatment of multidrug-resistant P. aeruginosa infections. ABSTRACT Polymyxins are currently the last-resort antibiotics for the… read more here.
Keywords: mvfr; resistance; treatment; polymyxin ... See more keywords
Drug Repurposing Targeting Pseudomonas aeruginosa MvfR Using Docking, Virtual Screening, Molecular Dynamics, and Free-Energy Calculations
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DOI: 10.3390/antibiotics11020185
Abstract: Pseudomonas aeruginosa is an opportunistic Gram-negative bacterium responsible for acute and chronic infections in planktonic state or in biofilms. The sessile structures are known to confer physical stability, increase virulence, and work as a protective… read more here.
Keywords: free energy; mvfr; energy calculations; pseudomonas aeruginosa ... See more keywords