Combined Probe Strategy to Increase the Enzymatic Digestion Rate and Accelerate the Renal Radioactivity Clearance of Peptide Radiotracers.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00051
Abstract: High and sustained renal radioactivity accumulation is a major challenge in peptide-based radionuclide imaging and therapy. However, neutral endopeptidase (NEP)-based enzymatic hydrolysis to release and excrete the radioactive fragments has been proven to be an… read more here.
Keywords: nota mvk; combined probe; peptide; rate ... See more keywords
Synthesis and radiolabelling of PSMA-targeted derivatives containing GYK/MVK cleavable linkers
Sign Up to like & getrecommendations! Published in 2023 at "Royal Society Open Science"
DOI: 10.1098/rsos.220950
Abstract: Targeted radionuclide therapy (TRT) is a promising strategy to treat different types of cancer. TRT relies on a targeting vector used to deliver a therapeutic radionuclide specifically to the tumour site. Several low molecular weight… read more here.
Keywords: cleavable linkers; synthesis radiolabelling; gyk; radiolabelling psma ... See more keywords
Novel mutation for disseminated superficial actinic porokeratosis and its functional impact at the protein level
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Dermatology"
DOI: 10.1111/bjd.18139
Abstract: Dermatologists, geneticists and researchers in the field of porokeratoses do all know and will agree that disseminated superficial actinic porokeratosis (DSAP) is genetically heterogeneous, and that the mevalonate pathway – in particular the gene mevalonate… read more here.
Keywords: disseminated superficial; novel mutation; superficial actinic; mvk ... See more keywords
Deep intronic variant in MVK as a cause for mevalonic aciduria initially presenting as non‐syndromic retinitis pigmentosa
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Genetics"
DOI: 10.1111/cge.14207
Abstract: Non‐syndromic retinitis pigmentosa (NSRP) is a clinically and genetically heterogeneous group of disorders characterized by progressive degeneration of the rod and cone photoreceptors, often leading to blindness. The evolving association of syndromic genes to cause… read more here.
Keywords: mvk; variant; syndromic retinitis; retinitis pigmentosa ... See more keywords
Evaluation of Met-Val-Lys as a Renal Brush Border Enzyme-Cleavable Linker to Reduce Kidney Uptake of 68Ga-Labeled DOTA-Conjugated Peptides and Peptidomimetics
Sign Up to like & getrecommendations! Published in 2020 at "Molecules"
DOI: 10.3390/molecules25173854
Abstract: High kidney uptake is a common feature of peptide-based radiopharmaceuticals, leading to reduced detection sensitivity for lesions adjacent to kidneys and lower maximum tolerated therapeutic dose. In this study, we evaluated if the Met-Val-Lys (MVK)… read more here.
Keywords: 68ga dota; ambz; dota; dota ambz ... See more keywords
Low-Copy Genes in Terpenoid Metabolism: The Evolution and Expression of MVK and DXR Genes in Angiosperms
Sign Up to like & getrecommendations! Published in 2020 at "Plants"
DOI: 10.3390/plants9040525
Abstract: Terpenoids are a diverse class of metabolites that impact plant metabolism in response to environmental cues. They are synthesized either via a predominantly cytosolic (MVA) pathway or a plastidic pathway (MEP). In Arabidopsis, several enzymes… read more here.
Keywords: mvk dxr; evolution expression; expression; mvk ... See more keywords
A mechanism for biogenic production and emission of MEK from MVK decoupled from isoprene biosynthesis
Sign Up to like & getrecommendations! Published in 2019 at "Atmospheric Chemistry and Physics"
DOI: 10.5194/acp-19-3125-2019
Abstract: Abstract. Methyl ethyl ketone (MEK) is an important compound in atmospheric chemistry. While attention has been paid mostly to anthropogenic sources of MEK, recently it has been shown that biogenic sources are globally as important… read more here.
Keywords: mek; production; mvk; chemistry ... See more keywords