Purification and Characterization of MxB.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0676-6_5
Abstract: MxB/Mx2 is an interferon-induced dynamin-like GTPase, which restricts a number of life-threatening viruses. Because of its N-terminal region, predicted to be intrinsically disordered, and its propensity to self-oligomerize, purification of the full-length protein has not… read more here.
Keywords: characterization mxb; mxb; biology; purification ... See more keywords
GTPase Activity of MxB Contributes to Its Nuclear Location, Interaction with Nucleoporins and Anti-HIV-1 Activity
Sign Up to like & getrecommendations! Published in 2020 at "Virologica Sinica"
DOI: 10.1007/s12250-020-00249-8
Abstract: The human myxovirus resistance 2 (Mx2/MxB) protein, a member of interferon (IFN)-inducible dynamin-like large GTPases, restricts a number of virus infections. Inhibition of these viruses occurs at poorly-defined steps after viral entry and has a… read more here.
Keywords: mxb; hiv; activity mxb; gtpase activity ... See more keywords
MXB inhibits murine cytomegalovirus.
Sign Up to like & getrecommendations! Published in 2018 at "Virology"
DOI: 10.1016/j.virol.2018.07.017
Abstract: The MX dynamin GTPases inhibit diverse viruses at early post-entry phases. While MXA acts antiviral against influenza viruses, the anti HIV-1 activity of MXB was discovered recently. Here, we have studied the antiviral effect of… read more here.
Keywords: inhibits murine; murine cytomegalovirus; mxb; mcmv ... See more keywords
CryoEM structure of MxB reveals a novel oligomerization interface critical for HIV restriction
Sign Up to like & getrecommendations! Published in 2017 at "Science Advances"
DOI: 10.1126/sciadv.1701264
Abstract: CryoEM structure of MxB tubes at 4.6 Å resolution reveals novel interfaces responsible for assembly and anti–HIV-1 activity. Human dynamin–like, interferon-induced myxovirus resistance 2 (Mx2 or MxB) is a potent HIV-1 inhibitor. Antiviral activity requires… read more here.
Keywords: cryoem structure; mxb; reveals novel; hiv ... See more keywords
Role of MxB in Alpha Interferon-Mediated Inhibition of HIV-1 Infection
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DOI: 10.1128/jvi.00422-18
Abstract: The results of this study reconcile the controversial reports regarding the anti-HIV-1 function of alpha interferon-induced MxB protein. In addition to the different cell types that may have contributed to the different observations, our data… read more here.
Keywords: alpha interferon; mxb; hiv; infection ... See more keywords
Polymorphisms of the MxA and MxB genes are associated with biochemical indices and viral subtypes in Yunnan HCV patients
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2023.1119805
Abstract: Introduction Hepatitis C virus (HCV) infection was the primary reason causing critical hepatic Q7 diseases. Although direct-acting antiviral agents (DAA) were widely used in clinics, anti-drug mutation, the outcome of patients with different viral subtypes,… read more here.
Keywords: viral subtypes; mxa mxb; mxb; hcv patients ... See more keywords
MxB Disrupts Hepatitis C Virus NS5A–CypA Complex: Insights From a Combined Theoretical and Experimental Approach
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.849084
Abstract: The human myxovirus resistance B (MxB) protein is an interferon-induced restriction factor that fights a wide range of viruses. We previously demonstrated that MxB binds to hepatitis C virus (HCV)-encoded non-structural protein 5A (NS5A) and… read more here.
Keywords: ns5a cypa; mxb; cypa ns5a; hepatitis virus ... See more keywords