Moxifloxacin Disrupts and Attenuates Aβ42 Fibril and Oligomer Formation: Plausibly Repositioning an Antibiotic as Therapeutic against Alzheimer's Disease.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00371
Abstract: The aggregation of Aβ42 is established as a key factor in the development of Alzheimer's disease (AD). Consequently, molecules that inhibit aggregation of peptide may lead to therapies to prevent or control AD. Several studies… read more here.
Keywords: aggregation; alzheimer disease; fibril oligomer; mxf ... See more keywords
Ostwald Ripening-Mediated Grafting of Metal-Organic Frameworks on a Single Colloidal Nanocrystal to Form Uniform and Controllable MXF.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b01563
Abstract: MXF, a metal-organic framework (MOF) that contains more than two components, such as heterogeneous inorganic nanoparticle@MOF (NP@MOF) with precisely defined structures, is important in applications such as catalysis, energy, and biochemistry. However, the ambiguous growth… read more here.
Keywords: ostwald ripening; mediated grafting; colloidal nanocrystal; mof ... See more keywords
Comparing efficacies of moxifloxacin, levofloxacin and gatifloxacin in tuberculosis granulomas using a multi-scale systems pharmacology approach
Sign Up to like & getrecommendations! Published in 2017 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1005650
Abstract: Granulomas are complex lung lesions that are the hallmark of tuberculosis (TB). Understanding antibiotic dynamics within lung granulomas will be vital to improving and shortening the long course of TB treatment. Three fluoroquinolones (FQs) are… read more here.
Keywords: pharmacology approach; granulomas; mxf; systems pharmacology ... See more keywords