Targeting the ubiquitin‐proteasome system in a pancreatic cancer subtype with hyperactive MYC
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DOI: 10.1002/1878-0261.12835
Abstract: The myelocytomatosis oncogene (MYC) is an important driver in a subtype of pancreatic ductal adenocarcinoma (PDAC). However, MYC remains a challenging therapeutic target; therefore, identifying druggable synthetic lethal interactions in MYC‐active PDAC may lead to… read more here.
Keywords: pdac; hyperactive myc; proteasome system; myc ... See more keywords
A synthetic benzoxazine dimer derivative targets c-Myc to inhibit colorectal cancer progression.
Sign Up to like & getrecommendations! Published in 2025 at "Molecular oncology"
DOI: 10.1002/1878-0261.70127
Abstract: The c-Myc protein is a well-known oncoprotein that plays a crucial role in regulating cell growth, proliferation, and differentiation. The overexpression or dysregulation of c-Myc is commonly associated with tumorigenesis in several cancers, including colorectal… read more here.
Keywords: colorectal cancer; synthetic benzoxazine; myc; dimer ... See more keywords
A Selective Small‐Molecule c‐Myc Degrader Potently Regresses Lethal c‐Myc Overexpressing Tumors
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DOI: 10.1002/advs.202104344
Abstract: MYC oncogene is involved in the majority of human cancers and is often associated with poor outcomes, rendering it an extraordinarily desirable target, but therapeutic targeting of c‐Myc protein has been a challenge for >30… read more here.
Keywords: potently regresses; overexpressing tumors; lethal myc; myc ... See more keywords
“Double hit” anaplastic large cell lymphoma with concurrent ALK and MYC rearrangements
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Hematology"
DOI: 10.1002/ajh.25980
Abstract: A 28-year-old man presented with a history of persistent left groin swelling for 2 years, which has shown slow growth in recent 2 months. He denied any B symptoms including fever, night sweats, and weight… read more here.
Keywords: lymphoma; double hit; image; alk ... See more keywords
Circ‐Sirt1 inhibits vascular smooth muscle cells proliferation via the c‐Myc/cyclin B1 axis
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DOI: 10.1002/cbin.11758
Abstract: Vascular smooth muscle cells (VSMCs) are an important cellular component of the vascular wall. Restenosis is mainly due to VSMC excessive proliferation. However, little is known about the role of circRNAs in VSMC proliferation and… read more here.
Keywords: myc; vsmcs; circ sirt1; proliferation ... See more keywords
Keratin 23 Is a Peroxisome Proliferator‐Activated Receptor Alpha–Dependent, MYC‐Amplified Oncogene That Promotes Hepatocyte Proliferation
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology"
DOI: 10.1002/hep.30530
Abstract: Chronic activation of the nuclear receptor peroxisome proliferator–activated receptor alpha (PPARA) promotes MYC‐linked hepatocellular carcinoma (HCC) in mice. Recent studies have shown that MYC can function as an amplifier of transcription where MYC does not… read more here.
Keywords: peroxisome proliferator; ppara; proliferation; expression ... See more keywords
Dissecting the impact of bromodomain inhibitors on the Interferon Regulatory Factor 4‐MYC oncogenic axis in multiple myeloma
Sign Up to like & getrecommendations! Published in 2022 at "Hematological Oncology"
DOI: 10.1002/hon.3016
Abstract: B‐cell progenitor fate determinant interferon regulatory factor 4 (IRF4) exerts key roles in the pathogenesis and progression of multiple myeloma (MM), a currently incurable plasma cell malignancy. Aberrant expression of IRF4 and the establishment of… read more here.
Keywords: irf4; cell; myc; interferon regulatory ... See more keywords
Inhibition of MYC attenuates tumor cell self‐renewal and promotes senescence in SMARCB1‐deficient Group 2 atypical teratoid rhabdoid tumors to suppress tumor growth in vivo
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Cancer"
DOI: 10.1002/ijc.31873
Abstract: Loss of SMARCB1 is the hallmark genetic event that characterizes rhabdoid tumors in children. Rhabdoid tumors of the brain (ATRT) occur in young children and are particularly challenging with poor long‐term survival. SMARCB1 is a… read more here.
Keywords: rhabdoid tumors; tumor; inhibition; cell ... See more keywords
Feedback-regulated transcriptional repression of FBXO31 by c-Myc triggers ovarian cancer tumorigenesis.
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DOI: 10.1002/ijc.33854
Abstract: FBXO31, a member of F-box protein family, has been shown to play an important role in preventing tumorigenesis by preserving genomic stability during cell proliferations as well as upon genotoxic stresses. Inactivation of FBXO31 due… read more here.
Keywords: tumorigenesis; fbxo31; ovarian cancer; expression ... See more keywords
Endothelial c‐Myc and Doxorubicin‐Induced Metabolic Alterations: A Multi‐Organ Optical Imaging Study
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DOI: 10.1002/jbio.70037
Abstract: Endothelial c‐Myc plays a critical role in redox homeostasis, with its deletion potentially exacerbating oxidative stress, particularly, during chemotherapy. read more here.
Keywords: endothelial myc; metabolic alterations; myc; myc doxorubicin ... See more keywords
Image duplication in E Galmozzi et al, J Cell Physiol, 200 (2004), pp. 82‐88
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DOI: 10.1002/jcp.29745
Abstract: To the Editor, E. Galmozzi, P. Casalini, M. V. Iorio, B. Casati, C. Olgiati, S. Ménard. HER2 signaling enhances 5′‐UTR‐mediated translation of c‐Myc mRNA, J Cell Physiol, 200 (2004), pp. 82‐88 reports that “HRG stimulation… read more here.
Keywords: physiol 200; galmozzi; cell physiol; 200 2004 ... See more keywords