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   Articles with "myc bcl2" as a keyword



Treatment outcomes of zanubrutinib-based regimen in newly diagnosed patients with MYC/BCL2 double-expressor diffuse large B-cell lymphoma: a retrospective multicenter real-world study

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recommendations! Published in 2025 at "Annals of Hematology"

DOI: 10.1007/s00277-025-06669-4

Abstract: Diffuse large B-cell lymphoma (DLBCL) patients with co-expression of MYC (≥ 40%) and BCL2 (≥ 50%), classified as double-expressor DLBCL (DE-DLBCL), consistently exhibit poor prognosis with traditional first-line therapies. In order to address the unmet therapeutic needs… read more here.

Keywords: myc bcl2; cell lymphoma; cell; diffuse large ... See more keywords

High grade B-cell lymphoma with rearrangements of MYC and BCL2 and/or BCL6: Double hit and triple hit lymphomas and double expressing lymphoma.

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recommendations! Published in 2017 at "Blood reviews"

DOI: 10.1016/j.blre.2016.09.004

Abstract: Diffuse large B-cell lymphomas with aberrations in MYC, BCL2 and/or BCL6 by genetic alterations or protein expression represent a group of high grade B-cell lymphomas with inferior outcomes when treated with standard RCHOP chemotherapy. As… read more here.

Keywords: lymphoma; bcl2 bcl6; high grade; myc bcl2 ... See more keywords
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Somatic copy number gains in MYC, BCL2, and BCL6 identifies a subset of aggressive alternative-DH/TH DLBCL patients

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recommendations! Published in 2020 at "Blood Cancer Journal"

DOI: 10.1038/s41408-020-00382-3

Abstract: Double/triple hit lymphoma (DH/TH), known as high-grade B-cell lymphoma (HGBL), is an aggressive diffuse large B cell lymphoma (DLBCL), defined as having concurrent MYC, BCL2, and/or BCL6 gene rearrangements. While gene rearrangements represent significant genetic… read more here.

Keywords: bcl2 bcl6; copy number; dlbcl; myc bcl2 ... See more keywords

Terminal Deoxynucleotidyl Transferase (TdT) Positive Acute Myeloid Leukemia with C-MYC and BCL2 Expression: A Distinct Biological Entity with Potential Clinical Implications

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recommendations! Published in 2025 at "Indian Journal of Medical and Paediatric Oncology"

DOI: 10.1055/s-0045-1809173

Abstract: Abstract Terminal deoxynucleotidyl transferase (TdT) is a unique deoxyribonucleic acid polymerase whose overexpression has been used as an important biomarker in the diagnosis of precursor B or T cell acute lymphoblastic leukemia/lymphoma. Over the last… read more here.

Keywords: tdt; leukemia; myc; myc bcl2 ... See more keywords
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MYC and BCL2 evaluation in routine diagnostics of aggressive B‐cell lymphomas – presentation of a work‐flow and the experience with 248 cases

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recommendations! Published in 2017 at "British Journal of Haematology"

DOI: 10.1111/bjh.14250

Abstract: Keywords: MYC ; immunohistochemistry; fluorescence in situ hybridization; diffuse large B-cell lymphoma; double-hit lymphomas read more here.

Keywords: routine diagnostics; myc bcl2; evaluation routine; bcl2 evaluation ... See more keywords
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Venetoclax improves CD20 immunotherapy in a mouse model of MYC/BCL2 double-expressor diffuse large B-cell lymphoma

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recommendations! Published in 2023 at "Journal for Immunotherapy of Cancer"

DOI: 10.1136/jitc-2022-006113

Abstract: Background Approximately one-third of diffuse large B cell lymphoma (DLBCL) patients exhibit co-expression of MYC and BCL2 (double-expressor lymphoma, DEL) and have a dismal prognosis. Targeted inhibition of the anti-apoptotic protein BCL2 with venetoclax (ABT-199)… read more here.

Keywords: bcl2; myc bcl2; cell; lymphoma ... See more keywords

Primary Diffuse Large B-Cell Lymphoma of the Breast with MYC and BCL2 Rearrangements with Terminal Deoxynucleotidyl Transferase Expression: A Case Report

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recommendations! Published in 2024 at "Case Reports in Oncology"

DOI: 10.1159/000536551

Abstract: Abstract Introduction: Primary breast lymphoma represents only 1% of non-Hodgkin lymphomas. The most common histology is diffuse large B-cell lymphoma. When dual translocations of MYC and BCL2 or BCL6 occur, it is referred to as… read more here.

Keywords: case; cell lymphoma; breast; myc bcl2 ... See more keywords

COO, MYC / BCL2 Status and R-IPI Define a Group of Poor Prognosis DLBCL Patients in a Real-World Clinical Setting

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recommendations! Published in 2019 at "Blood"

DOI: 10.1182/blood-2019-125689

Abstract: BACKGROUND In DLBCL, and mainly in advanced-stage, the presence of an activated B-cell phenotype or a non-GCB phenotype, and the coexpression of Myc and Bcl2 protein by IHC, are usually considered to be associated with… read more here.

Keywords: dlbcl; myc bcl2; bcl2; stage ... See more keywords
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High-Grade B-Cell Lymphomas with MYC and BCL2 Translocations Lack Tumor-Associated Macrophages and PD-L1 Expression: A Possible Noninflamed Subgroup

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recommendations! Published in 2020 at "Blood"

DOI: 10.1182/blood-2020-134411

Abstract: Extensive molecular analysis of large B-cell lymphomas (LBCL) have provided basis for new concepts of lymphoma taxonomy. These include stages of differentiation, phenotype (cell of origin) as well as genotype (including, but not confined to… read more here.

Keywords: tumor associated; myc bcl2; expression; bcl2 ... See more keywords

Comprehensive genomic profiling of diffuse large B cell lymphoma using targeted NGS: Insights into MYC, BCL2, and BCL6 rearrangements and beyond

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recommendations! Published in 2025 at "Blood"

DOI: 10.1182/blood-2025-5310

Abstract: Introduction Diffuse large B-cell lymphoma (DLBCL) harbors recurrent gene rearrangements, particularly involving MYC, BCL2, and BCL6. While FISH is the current standard for detecting these events, next-generation sequencing (NGS) offers a comprehensive approach by identifying… read more here.

Keywords: lymphoma; bcl2 bcl6; cell; targeted ngs ... See more keywords

--The double hit signature identifies double-hit diffuse large B-cell lymphoma with genetic events cryptic to FISH.

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recommendations! Published in 2019 at "Blood"

DOI: 10.1182/blood.2019002600

Abstract: High-grade B-cell lymphomas with MYC and BCL2 and/or BCL6 rearrangements (HGBL-DH/TH) includes a group of diffuse large B-cell lymphomas with inferior outcomes following standard chemoimmunotherapy. We recently described a gene expression signature that identifies 27%… read more here.

Keywords: double hit; cell; myc bcl2; large cell ... See more keywords