High grade B-cell lymphoma with rearrangements of MYC and BCL2 and/or BCL6: Double hit and triple hit lymphomas and double expressing lymphoma.
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DOI: 10.1016/j.blre.2016.09.004
Abstract: Diffuse large B-cell lymphomas with aberrations in MYC, BCL2 and/or BCL6 by genetic alterations or protein expression represent a group of high grade B-cell lymphomas with inferior outcomes when treated with standard RCHOP chemotherapy. As… read more here.
Keywords: lymphoma; bcl2 bcl6; high grade; myc bcl2 ... See more keywords
Somatic copy number gains in MYC, BCL2, and BCL6 identifies a subset of aggressive alternative-DH/TH DLBCL patients
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DOI: 10.1038/s41408-020-00382-3
Abstract: Double/triple hit lymphoma (DH/TH), known as high-grade B-cell lymphoma (HGBL), is an aggressive diffuse large B cell lymphoma (DLBCL), defined as having concurrent MYC, BCL2, and/or BCL6 gene rearrangements. While gene rearrangements represent significant genetic… read more here.
Keywords: bcl2 bcl6; copy number; dlbcl; myc bcl2 ... See more keywords
MYC and BCL2 evaluation in routine diagnostics of aggressive B‐cell lymphomas – presentation of a work‐flow and the experience with 248 cases
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Haematology"
DOI: 10.1111/bjh.14250
Abstract: Keywords: MYC ; immunohistochemistry; fluorescence in situ hybridization; diffuse large B-cell lymphoma; double-hit lymphomas read more here.
Keywords: routine diagnostics; myc bcl2; evaluation routine; bcl2 evaluation ... See more keywords
Venetoclax improves CD20 immunotherapy in a mouse model of MYC/BCL2 double-expressor diffuse large B-cell lymphoma
Sign Up to like & getrecommendations! Published in 2023 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-006113
Abstract: Background Approximately one-third of diffuse large B cell lymphoma (DLBCL) patients exhibit co-expression of MYC and BCL2 (double-expressor lymphoma, DEL) and have a dismal prognosis. Targeted inhibition of the anti-apoptotic protein BCL2 with venetoclax (ABT-199)… read more here.
Keywords: bcl2; myc bcl2; cell; lymphoma ... See more keywords
COO, MYC / BCL2 Status and R-IPI Define a Group of Poor Prognosis DLBCL Patients in a Real-World Clinical Setting
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DOI: 10.1182/blood-2019-125689
Abstract: BACKGROUND In DLBCL, and mainly in advanced-stage, the presence of an activated B-cell phenotype or a non-GCB phenotype, and the coexpression of Myc and Bcl2 protein by IHC, are usually considered to be associated with… read more here.
Keywords: dlbcl; myc bcl2; bcl2; stage ... See more keywords
High-Grade B-Cell Lymphomas with MYC and BCL2 Translocations Lack Tumor-Associated Macrophages and PD-L1 Expression: A Possible Noninflamed Subgroup
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DOI: 10.1182/blood-2020-134411
Abstract: Extensive molecular analysis of large B-cell lymphomas (LBCL) have provided basis for new concepts of lymphoma taxonomy. These include stages of differentiation, phenotype (cell of origin) as well as genotype (including, but not confined to… read more here.
Keywords: tumor associated; myc bcl2; expression; bcl2 ... See more keywords
--The double hit signature identifies double-hit diffuse large B-cell lymphoma with genetic events cryptic to FISH.
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DOI: 10.1182/blood.2019002600
Abstract: High-grade B-cell lymphomas with MYC and BCL2 and/or BCL6 rearrangements (HGBL-DH/TH) includes a group of diffuse large B-cell lymphomas with inferior outcomes following standard chemoimmunotherapy. We recently described a gene expression signature that identifies 27%… read more here.
Keywords: double hit; cell; myc bcl2; large cell ... See more keywords
Extra copies of MYC, BCL2, and BCL6 and outcome in patients with diffuse large B-cell lymphoma.
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DOI: 10.1182/bloodadvances.2020001551
Abstract: High-grade B-cell lymphoma (HGBL) with translocations involving MYC and BCL2 or BCL6 comprises ∼10% of cases of diffuse large B-cell lymphoma (DLBCL) and carries a poor prognosis. The incidence, prognosis, and optimal therapy for DLBCL… read more here.
Keywords: bcl2 bcl6; myc bcl2; copies myc; extra copies ... See more keywords
The outcome of high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements or NOS compared to DLBCL patients from a single institution.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.7560
Abstract: 7560Background: 2016 update of the WHO 2008 classification of lymphoid neoplasms introduced new categories of highly aggressive B lymphomas (BCL): high grade B lymphoma (HGBL) with MYC and BCL2 and... read more here.
Keywords: outcome high; high grade; myc bcl2; grade cell ... See more keywords
Diffuse large B-cell lymphoma with concurrent high MYC and BCL2 expression shows evidence of active B-cell receptor signaling by quantitative immunofluorescence
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DOI: 10.1371/journal.pone.0172364
Abstract: B-cell receptor (BCR)-mediated signaling plays an important role in the pathogenesis of a subset of diffuse large B-cell lymphoma (DLBCL), and novel agents targeting this pathway are now in clinical use. We have previously identified… read more here.
Keywords: bcr; high myc; myc bcl2; expression ... See more keywords
Real world data on young patients with high-risk diffuse large B-cell lymphoma treated with R-CHOP or R-CHOEP - MYC, BCL2 and BCL6 as prognostic biomarkers
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DOI: 10.1371/journal.pone.0186983
Abstract: Background Double expression of MYC and BCL2 proteins (DE) and double-hit MYC+BCL2/BCL6 translocations (DH) were established as important biomarkers in patients with diffuse large B-cell lymphoma (DLBCL) by the 2016 revision of the World Health… read more here.
Keywords: treated chop; choep; high risk; myc bcl2 ... See more keywords