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1
Published in 2017 at "Blood reviews"
DOI: 10.1016/j.blre.2016.09.004
Abstract: Diffuse large B-cell lymphomas with aberrations in MYC, BCL2 and/or BCL6 by genetic alterations or protein expression represent a group of high grade B-cell lymphomas with inferior outcomes when treated with standard RCHOP chemotherapy. As…
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Keywords:
lymphoma;
bcl2 bcl6;
high grade;
myc bcl2 ... See more keywords
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1
Published in 2020 at "Blood Cancer Journal"
DOI: 10.1038/s41408-020-00382-3
Abstract: Double/triple hit lymphoma (DH/TH), known as high-grade B-cell lymphoma (HGBL), is an aggressive diffuse large B cell lymphoma (DLBCL), defined as having concurrent MYC, BCL2, and/or BCL6 gene rearrangements. While gene rearrangements represent significant genetic…
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Keywords:
bcl2 bcl6;
copy number;
dlbcl;
myc bcl2 ... See more keywords
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1
Published in 2017 at "British Journal of Haematology"
DOI: 10.1111/bjh.14250
Abstract: Keywords: MYC ; immunohistochemistry; fluorescence in situ hybridization; diffuse large B-cell lymphoma; double-hit lymphomas
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Keywords:
routine diagnostics;
myc bcl2;
evaluation routine;
bcl2 evaluation ... See more keywords
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2
Published in 2023 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-006113
Abstract: Background Approximately one-third of diffuse large B cell lymphoma (DLBCL) patients exhibit co-expression of MYC and BCL2 (double-expressor lymphoma, DEL) and have a dismal prognosis. Targeted inhibition of the anti-apoptotic protein BCL2 with venetoclax (ABT-199)…
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Keywords:
bcl2;
myc bcl2;
cell;
lymphoma ... See more keywords
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1
Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-125689
Abstract: BACKGROUND In DLBCL, and mainly in advanced-stage, the presence of an activated B-cell phenotype or a non-GCB phenotype, and the coexpression of Myc and Bcl2 protein by IHC, are usually considered to be associated with…
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Keywords:
dlbcl;
myc bcl2;
bcl2;
stage ... See more keywords
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1
Published in 2020 at "Blood"
DOI: 10.1182/blood-2020-134411
Abstract: Extensive molecular analysis of large B-cell lymphomas (LBCL) have provided basis for new concepts of lymphoma taxonomy. These include stages of differentiation, phenotype (cell of origin) as well as genotype (including, but not confined to…
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Keywords:
tumor associated;
myc bcl2;
expression;
bcl2 ... See more keywords
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Published in 2019 at "Blood"
DOI: 10.1182/blood.2019002600
Abstract: High-grade B-cell lymphomas with MYC and BCL2 and/or BCL6 rearrangements (HGBL-DH/TH) includes a group of diffuse large B-cell lymphomas with inferior outcomes following standard chemoimmunotherapy. We recently described a gene expression signature that identifies 27%…
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Keywords:
double hit;
cell;
myc bcl2;
large cell ... See more keywords
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1
Published in 2020 at "Blood advances"
DOI: 10.1182/bloodadvances.2020001551
Abstract: High-grade B-cell lymphoma (HGBL) with translocations involving MYC and BCL2 or BCL6 comprises ∼10% of cases of diffuse large B-cell lymphoma (DLBCL) and carries a poor prognosis. The incidence, prognosis, and optimal therapy for DLBCL…
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Keywords:
bcl2 bcl6;
myc bcl2;
copies myc;
extra copies ... See more keywords
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2
Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.7560
Abstract: 7560Background: 2016 update of the WHO 2008 classification of lymphoid neoplasms introduced new categories of highly aggressive B lymphomas (BCL): high grade B lymphoma (HGBL) with MYC and BCL2 and...
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Keywords:
outcome high;
high grade;
myc bcl2;
grade cell ... See more keywords
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1
Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0172364
Abstract: B-cell receptor (BCR)-mediated signaling plays an important role in the pathogenesis of a subset of diffuse large B-cell lymphoma (DLBCL), and novel agents targeting this pathway are now in clinical use. We have previously identified…
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Keywords:
bcr;
high myc;
myc bcl2;
expression ... See more keywords
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1
Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0186983
Abstract: Background Double expression of MYC and BCL2 proteins (DE) and double-hit MYC+BCL2/BCL6 translocations (DH) were established as important biomarkers in patients with diffuse large B-cell lymphoma (DLBCL) by the 2016 revision of the World Health…
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Keywords:
treated chop;
choep;
high risk;
myc bcl2 ... See more keywords