Two diphosphorylated degrons control c-Myc degradation by the Fbw7 tumor suppressor
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DOI: 10.1126/sciadv.abl7872
Abstract: c-Myc (hereafter, Myc) is a cancer driver whose abundance is regulated by the SCFFbw7 ubiquitin ligase and proteasomal degradation. Fbw7 binds to a phosphorylated Myc degron centered at threonine 58 (T58), and mutations of Fbw7… read more here.
Keywords: myc degradation; fbw7; degradation; two diphosphorylated ... See more keywords
The Circadian Clock Protein CRY2 Promotes MYC Degradation.
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DOI: 10.1158/2159-8290.cd-rw2016-215
Abstract: CRY2 recruits SCFFBXL3 to ubiquitinate MYC, promoting MYC degradation and preventing transformation. read more here.
Keywords: protein cry2; clock protein; circadian clock; myc degradation ... See more keywords