Targeting protein folding in N‐Myc‐driven medulloblastoma
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13395
Abstract: Selective targeting of N‐Myc‐driven Sonic hedgehog (SHH) medulloblastoma has been a challenge for many years and, despite decades of research, few targeted therapy opportunities exist. Recently, Kuzuoglu‐Ozturk et al. characterized the translatome of N‐Myc‐driven medulloblastoma… read more here.
Keywords: protein folding; targeting protein; folding myc; myc driven ... See more keywords
Histone-lysine N-methyltransferase EHMT2 (G9a) inhibition mitigates tumorigenicity in Myc-driven liver cancer.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular oncology"
DOI: 10.1002/1878-0261.13417
Abstract: Hepatocellular carcinoma (HCC) is the third deadliest and sixth most common cancer in the world. Histone-lysine N-methyltransferase EHMT2 (also known as G9a) is a histone methyltransferase frequently overexpressed in many cancer types, including HCC. We… read more here.
Keywords: driven liver; histone; g9a; myc driven ... See more keywords
Novel MYC-driven medulloblastoma models from multiple embryonic cerebellar cells
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2017.110
Abstract: Group3 medulloblastoma (MBG3) that predominantly occur in young children are usually associated with MYC amplification and/or overexpression, frequent metastasis and a dismal prognosis. Physiologically relevant MBG3 models are currently lacking, making inferences related to their… read more here.
Keywords: embryonic cerebellar; novel myc; myc driven; driven medulloblastoma ... See more keywords
Combined BET bromodomain and CDK2 inhibition in MYC-driven medulloblastoma
Sign Up to like & getrecommendations! Published in 2018 at "Oncogene"
DOI: 10.1038/s41388-018-0135-1
Abstract: Medulloblastoma (MB) is the most common malignant brain tumor in children. MYC genes are frequently amplified and correlate with poor prognosis in MB. BET bromodomains recognize acetylated lysine residues and often promote and maintain MYC… read more here.
Keywords: bet bromodomain; medulloblastoma; inhibition; myc driven ... See more keywords
Therapeutic targeting nudix hydrolase 1 creates a MYC-driven metabolic vulnerability
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-46572-6
Abstract: Tumor cells must rewire nucleotide synthesis to satisfy the demands of unbridled proliferation. Meanwhile, they exhibit augmented reactive oxygen species (ROS) production which paradoxically damages DNA and free deoxy-ribonucleoside triphosphates (dNTPs). How these metabolic processes… read more here.
Keywords: metabolic vulnerability; myc driven; nudix hydrolase; driven metabolic ... See more keywords
An MXD1-derived repressor peptide identifies noncoding mediators of MYC-driven cell proliferation
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1921786117
Abstract: Significance MYC is a transcriptional regulator that controls much of the coding and noncoding transcriptome. It is also an oncoprotein that functions as a driver in numerous human cancers. The mechanism of this oncogenic activity… read more here.
Keywords: repressor; cell proliferation; proliferation; myc driven ... See more keywords
IMMU-19. HDAC INHIBITORS SENSITIZE MYC-AMPLIFIED MEDULLOBLASTOMA TO IMMUNOTHERAPY BY ACTIVATING THE NF-kB PATHWAYS
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaa222.375
Abstract: Abstract Medulloblastoma is the most common malignant brain tumor in childhood and comprises four distinct molecular subgroups with further layers of intertumoral heterogeneity. Amplification of the oncogene MYC drives tumorigenesis and constitutes a hallmark feature… read more here.
Keywords: hdac inhibitors; myc driven; immu hdac; inhibitors sensitize ... See more keywords
MBRS-26. CDK7 MEDIATED TRANSCRIPTIONAL PROCESSIVITY OF DNA REPAIR NETWORKS REGULATES SENSITIVITY TO RADIATION IN MYC DRIVEN MEDULLOBLASTOMA
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaa222.541
Abstract: Abstract Myc-driven Medulloblastoma remains a major therapeutic challenge due to frequent metastasis and a poor 5-year survival rate. Myc overexpression results in transcriptional dysregulation, proliferation, and survival of malignant cells. To identify therapeutic targets in… read more here.
Keywords: cdk7; dna repair; dna; myc driven ... See more keywords
Intratumoral heterogeneity of MYC drives medulloblastoma metastasis and angiogenesis.
Sign Up to like & getrecommendations! Published in 2022 at "Neuro-oncology"
DOI: 10.1093/neuonc/noac068
Abstract: BACKGROUND Intratumoral heterogeneity is crucially involved in metastasis, resistance to therapy and cancer relapse. Amplifications of the proto-oncogene MYC display notable heterogeneity at the single-cell level and are associated with a particularly dismal prognosis in… read more here.
Keywords: metastasis; heterogeneity; cell; myc driven ... See more keywords
MDB-18. SYNERGISTIC TARGETING OF CDK8 AND MTOR FOR MYC-DRIVEN MEDULLOBLASTOMA
Sign Up to like & getrecommendations! Published in 2024 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noae064.467
Abstract: Abstract MYC-driven medulloblastoma represents a highly aggressive subgroup with poor prognosis and limited treatment options. CRISPR-Cas9 screening across MB cell lines revealed cyclin-dependent kinase 8 (CDK8) as a top dependency for MB growth. Loss of… read more here.
Keywords: targeting cdk8; cdk8; myc driven; driven medulloblastoma ... See more keywords
Stressing Myc-driven cancer out
Sign Up to like & getrecommendations! Published in 2018 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aar7535
Abstract: Myc-driven cancers can be targeted with the IRE1α inhibitor. Myc-driven cancers can be targeted with the IRE1α inhibitor. read more here.
Keywords: medicine; driven cancer; stressing myc; myc driven ... See more keywords