MYC expression is associated with older age, common morphology, increased MYC copy number, and poorer prognosis in patients with ALK+ anaplastic large cell lymphoma.
Sign Up to like & getrecommendations! Published in 2020 at "Human pathology"
DOI: 10.1016/j.humpath.2020.11.002
Abstract: The role of MYC dysregulation has been studied extensively in B cell lymphomas, but little is known about its significance in T cell lymphomas. This study, for the first time in the literature, assessed the… read more here.
Keywords: increased myc; copy number; myc expression; myc copy ... See more keywords
FBXL6 is dysregulated in keloids and promotes keloid fibroblast growth by inducing c‐Myc expression
Sign Up to like & getrecommendations! Published in 2022 at "International Wound Journal"
DOI: 10.1111/iwj.13847
Abstract: C‐MYC‐mediated keloid fibroblasts proliferation and collagen deposit may contribute to the development of keloids. F‐box and leucine‐rich repeat protein 6 (FBXL6) is reported to be involved in tumour progression, while the role of FBXL6 in… read more here.
Keywords: myc expression; expression fbxl6; fbxl6; expression ... See more keywords
TAF Family Proteins and MEF2C Are Essential for Epstein-Barr Virus Super-Enhancer Activity
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Virology"
DOI: 10.1128/jvi.00513-19
Abstract: SEs play critical roles in cancer development. Since SEs assemble much bigger protein complexes on enhancers than typical enhancers (TEs), they are more sensitive than TEs to perturbations. Understanding the protein composition of SEs that… read more here.
Keywords: expression; myc expression; activity; virus ... See more keywords
Metabolic Imaging Detects Low Levels of Glycolytic Activity That Vary with Levels of c-Myc Expression in Patient-Derived Xenograft Models of Glioblastoma.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer research"
DOI: 10.1158/0008-5472.can-18-0759
Abstract: 13C MRI of hyperpolarized [1-13C]pyruvate metabolism has been used in oncology to detect disease, investigate disease progression, and monitor response to treatment with a view to guiding treatment in individual patients. This technique has translated… read more here.
Keywords: myc expression; 13c pyruvate; hyperpolarized 13c; patient derived ... See more keywords
APTO-253 Stabilizes G-quadruplex DNA, Inhibits MYC Expression, and Induces DNA Damage in Acute Myeloid Leukemia Cells
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DOI: 10.1158/1535-7163.mct-17-1209
Abstract: APTO-253 is a phase I clinical stage small molecule that selectively induces CDKN1A (p21), promotes G0–G1 cell-cycle arrest, and triggers apoptosis in acute myeloid leukemia (AML) cells without producing myelosuppression in various animal species and… read more here.
Keywords: dna; myeloid leukemia; myc expression; expression ... See more keywords
Abstract 3948: DDX5 helicase resolves G-quadruplex and transactivates MYC expression
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3948
Abstract: DDX5 (DEAD-box protein 5) plays an important role in cell proliferation, differentiation, and tumorigenesis. DDX5 is a founding member of the DEAD-box RNA helicase family and known as a non-processive RNA helicase. It acts as… read more here.
Keywords: myc expression; dna; ddx5; helicase ... See more keywords
Abstract 6233: Omacetaxine reduces c-MYC expression and demonstrates antitumor effects in osteosarcoma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-6233
Abstract: Omacetaxine mepesuccinate (OMX), also known as homoharringtonine, is a protein translation inhibitor approved for use in chronic myeloid leukemia. Recent studies suggest OMX may be effective against other cancer types with high rates of protein… read more here.
Keywords: myc expression; omacetaxine reduces; expression demonstrates; reduces myc ... See more keywords
Identification of G-Quadruplex-Binding Inhibitors of Myc Expression through Affinity Selection–Mass Spectrometry
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DOI: 10.1177/2472555218796656
Abstract: The Myc oncogene is overexpressed in many cancers, yet targeting it for cancer therapy has remained elusive. One strategy for inhibition of Myc expression is through stabilization of the G-quadruplex (G4), a G-rich DNA secondary… read more here.
Keywords: affinity selection; selection mass; mass spectrometry; myc expression ... See more keywords
MYC Expression in Systemic Anaplastic Large Cell Lymphoma: Clinicopathologic and Prognostic Features of 70 Patients
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-124556
Abstract: Background: Dysregulation of MYC has oncogenic potential. It has been reported that MYC dysregulation (gene rearrangement, increased copy number, and protein overexpression) predicts poorer prognosis in patients with diffuse large B cell lymphoma. Systemic anaplastic… read more here.
Keywords: alcl; expression; alk negative; myc expression ... See more keywords
Knocking-down of CREPT prohibits the progression of oral squamous cell carcinoma and suppresses cyclin D1 and c-Myc expression
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DOI: 10.1371/journal.pone.0174309
Abstract: Background As a regulator essential for many cell cycle-related proteins, the robust expression of Cell cycle-Related and Expression-elevated Protein in Tumor (CREPT) implicates a poor diagnosis of endoderm and mesoderm-derived tumors. Whether CREPT plays the… read more here.
Keywords: knocking crept; cyclin myc; myc expression; expression ... See more keywords
Therapeutic Potential of the Cyclin-Dependent Kinase Inhibitor Flavopiridol on c-Myc Overexpressing Esophageal Cancer
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.746385
Abstract: Tumors with elevated c-Myc expression often exhibit a highly aggressive phenotype, and c-Myc amplification has been shown to be frequent in esophageal cancer. Emerging data suggests that synthetic lethal interactions between c-Myc pathway activation and… read more here.
Keywords: esophageal cancer; myc expression; flavopiridol; cancer ... See more keywords