Demystifying the Druggability of the MYC Family of Oncogenes.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c12732
Abstract: The MYC family of oncogenes (MYC, MYCN, and MYCL) encodes a basic helix-loop-helix leucine zipper (bHLHLZ) transcriptional regulator that is responsible for moving the cell through the restriction point. Through the HLHZIP domain, MYC heterodimerizes… read more here.
Keywords: myc family; myc max; myc; family oncogenes ... See more keywords
Clinical significance of MYC family protein expression in surgically resected high‐grade neuroendocrine carcinoma of the lung
Sign Up to like & getrecommendations! Published in 2023 at "Thoracic Cancer"
DOI: 10.1111/1759-7714.14804
Abstract: MYC family genes including MYC, MYCN, and MYCL are amplified and overexpressed as oncogenic drivers in high‐grade neuroendocrine carcinoma of the lung (HGNEC), but little is known about their clinical significance. This study evaluated the… read more here.
Keywords: myc family; grade neuroendocrine; high grade; family ... See more keywords