Cell Intrinsic and Extrinsic Mechanisms Mediate the Role of c-Myc Haploinsufficiency in Controlling HSC Fate
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DOI: 10.1182/blood-2018-99-116975
Abstract: It has been shown that loss of c-Myc leads to accumulation of hematopoietic stem cells (HSCs) and severe cytopenia as a consequence of a blockage of HSC differentiation. Here we report a role of c-Myc… read more here.
Keywords: mice; myc haploinsufficiency; myc; role myc ... See more keywords
Role of c-Myc haploinsufficiency in the maintenance of HSCs in mice.
Sign Up to like & getrecommendations! Published in 2021 at "Blood"
DOI: 10.1182/blood.2019004688
Abstract: This study was conducted to determine the dosage effect of c-Myc on hematopoiesis and its distinct role in mediating the Wnt/β-catenin pathway in hematopoietic stem cell (HSC) and bone marrow niche cells. c-Myc haploinsufficiency led… read more here.
Keywords: hscs; maintenance; haploinsufficiency; role ... See more keywords