Long path to MYC inhibition approaches clinical trials
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DOI: 10.1038/s41568-019-0141-9
Abstract: Omomyc, a MYC dominant-negative gene product that is used to inhibit MYC for research purposes, can penetrate cancer cells in vitro and in vivo, bringing it closer to evaluation in the clinic. read more here.
Keywords: long path; inhibition approaches; path myc; myc inhibition ... See more keywords
Innovative evaluation of selinexor and JQ1 synergy in leukemia therapy via C-MYC inhibition
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DOI: 10.1186/s12967-025-06525-z
Abstract: Acute myeloid leukemia (AML) remains a therapeutic challenge due to drug resistance and relapse. Selinexor, an XPO1 inhibitor, shows limited efficacy as monotherapy, necessitating combination strategies. JQ1, a BET inhibitor targeting MYC, may synergize with… read more here.
Keywords: selinexor jq1; leukemia; jq1; myc inhibition ... See more keywords