Anti-apoptotic A1 is not essential for lymphoma development in Eµ-Myc mice but helps sustain transplanted Eµ-Myc tumour cells
Sign Up to like & getrecommendations! Published in 2017 at "Cell Death and Differentiation"
DOI: 10.1038/s41418-017-0045-8
Abstract: The transcription factor c-MYC regulates a multiplicity of genes involved in cellular growth, proliferation, metabolism and DNA damage response and its overexpression is a hallmark of many tumours. Since MYC promotes apoptosis under conditions of… read more here.
Keywords: development myc; myc mice; lymphoma development; development ... See more keywords
Microbiota-driven interleukin-17-producing cells and eosinophils synergize to accelerate multiple myeloma progression
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-07305-8
Abstract: The gut microbiota has been causally linked to cancer, yet how intestinal microbes influence progression of extramucosal tumors is poorly understood. Here we provide evidence implying that Prevotella heparinolytica promotes the differentiation of Th17 cells… read more here.
Keywords: multiple myeloma; myc mice; gut microbiota; progression ... See more keywords
TRIP13 Modulates Protein Deubiquitination to Promote Myeloma Progression
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-123818
Abstract: Thyroid Hormone Receptor 13 (TRIP13) is an exciting emerging epitope in numerous cancers and is related to genomic integrity. In multiple myeloma (MM), TRIP13 is the third most upregulated gene in the 70-gene high-risk signature… read more here.
Keywords: myc mice; trip13; progression; trip13 myc ... See more keywords