High Wilms’ tumor 1 associating protein expression predicts poor prognosis in acute myeloid leukemia and regulates m6A methylation of MYC mRNA
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-020-03373-w
Abstract: Purpose Acute myeloid leukemia (AML) is a heterogenous disease and the survival of AML patients is largely attributed to the improvement of supportive treatment. Wilms’ tumor 1-associated protein (WTAP) is a nuclear protein functions in… read more here.
Keywords: methylation; myeloid leukemia; expression; myc mrna ... See more keywords
p62/SQSTM1 enhances breast cancer stem-like properties by stabilizing MYC mRNA
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DOI: 10.1038/onc.2016.202
Abstract: Aberrant p62 overexpression has been implicated in breast cancer development. Here, we found that p62 expression was elevated in breast cancer stem cells (BCSCs), including CD44+CD24− fractions, mammospheres, ALDH1+ populations and side population cells. Indeed,… read more here.
Keywords: p62; myc mrna; breast cancer;
MYC is downregulated by a mitochondrial checkpoint mechanism
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DOI: 10.18632/oncotarget.21653
Abstract: The MYC proto-oncogene serves as a rheostat coupling mitogenic signaling with the activation of genes regulating growth, metabolism and mitochondrial biogenesis. Here we describe a novel link between mitochondria and MYC levels. Perturbation of mitochondrial… read more here.
Keywords: mechanism; mitochondrial checkpoint; downregulated mitochondrial; myc downregulated ... See more keywords
Translation termination-dependent deadenylation of MYC mRNA in human cells
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DOI: 10.18632/oncotarget.25459
Abstract: The earliest step in the mRNA degradation process is deadenylation, a progressive shortening of the mRNA poly(A) tail by deadenylases. The question of when deadenylation takes place remains open. MYC mRNA is one of the… read more here.
Keywords: poly tail; translation termination; myc mrna; myc ... See more keywords
Reciprocal antagonistic regulation of N-myc mRNA by miR-17 and the neuronal-specific RNA-binding protein HuD
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DOI: 10.3892/or.2017.5664
Abstract: Neuroblastoma is a childhood cancer originating from embryonic neural crest cells. Amplification of the proto-oncogene N-myc, seen in ~30% of neuroblastoma tumors, is a marker for poor prognosis. Recently discovered small regulatory RNAs, microRNAs (miRNAs),… read more here.
Keywords: specific rna; neuronal specific; myc mrna; myc amplified ... See more keywords