In Silico Screening and Binding Characterization of Small Molecules toward a G-Quadruplex Structure Formed in the Promoter Region of c-MYC Oncogene
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DOI: 10.1021/acsomega.6b00531
Abstract: Overexpression of c-MYC oncogene is associated with cancer pathology. Expression of c-MYC is regulated by the G-quadruplex structure formed in the G-rich segment of nuclease hypersensitive element (NHE III1), that is, “Pu27”, which is localized… read more here.
Keywords: myc oncogene; promoter region; structure formed; quadruplex structure ... See more keywords
Abstract 3840: High-resolution structural insights into targeting the MYC oncogene G-quadruplex with the quinoline derivative PEQ
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3840
Abstract: The transcription of the MYC oncogene, a central player of oncogenesis, is strongly controlled by DNA G-quadruplexes in its promoter region (MycG4). Stabilization of MycG4 with small molecules downregulates MYC expression and has devastating effects… read more here.
Keywords: mycg4; peq; high resolution; cancer ... See more keywords
Crystal structure of the major quadruplex formed in the promoter region of the human c-MYC oncogene
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DOI: 10.1371/journal.pone.0205584
Abstract: The c-MYC oncogene mediates multiple tumor cell survival pathways and is dysregulated or overexpressed in the majority of human cancers. The NHE III1 region of the c-MYC promoter forms a DNA quadruplex. Stabilization of this… read more here.
Keywords: myc oncogene; crystal structure; quadruplex; structure ... See more keywords
Targeting the MYC Oncogene in Burkitt Lymphoma through HSP90 Inhibition
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DOI: 10.3390/cancers10110448
Abstract: Overexpression of the MYC oncogene is a key feature of many human malignancies including Burkitt lymphoma. While MYC is widely regarded to be a promising therapeutic target, a clinically effective MYC inhibitor is still elusive.… read more here.
Keywords: myc oncogene; burkitt lymphoma; hsp90; myc ... See more keywords
MYC Oncogene Contributions to Release of Cell Cycle Brakes
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DOI: 10.3390/genes10030244
Abstract: Promotion of the cell cycle is a major oncogenic mechanism of the oncogene c-MYC (MYC). MYC promotes the cell cycle by not only activating or inducing cyclins and CDKs but also through the downregulation or… read more here.
Keywords: cycle; cycle brakes; cell cycle; myc oncogene ... See more keywords