Prognostic significance of MYC oncoprotein expression on survival outcome in patients with acute myeloid leukemia with myelodysplasia related changes (AML-MRC).
Sign Up to like & getrecommendations! Published in 2019 at "Leukemia research"
DOI: 10.1016/j.leukres.2019.106194
Abstract: MYC is an oncoprotein that coordinates the expression of genes involved in metabolism, cell differentiation and survival in various types of malignancies. However, the underlying oncogenic mechanisms and the clinical significance of MYC expression in… read more here.
Keywords: aml mrc; expression; myc oncoprotein; myc ... See more keywords
Lysine-52 stabilizes the MYC oncoprotein through an SCFFbxw7-independent mechanism
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DOI: 10.1038/onc.2017.268
Abstract: The oncogenic transcription factor c-MYC (MYC) is deregulated and often overexpressed in more than 50% of cancers. MYC deregulation is associated with poor prognosis and aggressive disease, suggesting that the development of therapeutic inhibitors targeting… read more here.
Keywords: stabilizes myc; mechanism; scffbxw7 independent; myc oncoprotein ... See more keywords
The MYC oncoprotein directly interacts with its chromatin cofactor PNUTS to recruit PP1 phosphatase
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DOI: 10.1093/nar/gkac138
Abstract: Abstract Despite MYC dysregulation in most human cancers, strategies to target this potent oncogenic driver remain an urgent unmet need. Recent evidence shows the PP1 phosphatase and its regulatory subunit PNUTS control MYC phosphorylation, chromatin… read more here.
Keywords: myc oncoprotein; myc; interacts chromatin; directly interacts ... See more keywords
Abstract 5423: Lysine-52 stabilizes the MYC oncoprotein through a SCFFBXW7-independent mechanism
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-5423
Abstract: The oncogenic transcription factor c-MYC (MYC) is deregulated, and often overexpressed, in more than 50% of cancers. MYC deregulation is associated with poor prognosis and aggressive disease, suggesting that the development of therapeutic inhibitors targeting… read more here.
Keywords: stabilizes myc; mechanism; scffbxw7 independent; myc oncoprotein ... See more keywords