DNA Conformation Regulates Gene Expression: The MYC Promoter and Beyond
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DOI: 10.1002/bies.201700235
Abstract: Emerging evidence suggests that DNA topology plays an instructive role in cell fate control through regulation of gene expression. Transcription produces torsional stress, and the resultant supercoiling of the DNA molecule generates an array of… read more here.
Keywords: topology; gene expression; myc promoter; dna ... See more keywords
Structural insight for the recognition of G-quadruplex structure at human c-myc promoter sequence by flavonoid Quercetin
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DOI: 10.1038/s41598-017-03906-3
Abstract: Small molecule ligands that could stabilize G-quadruplex structure formed at the promoter region of human c-myc oncogene will regulate its expression in cancer cells. Flavonoids, a group of naturally available small molecule, have been known… read more here.
Keywords: quadruplex structure; myc promoter; structure; human myc ... See more keywords
Significant structural change in human c-Myc promoter G-quadruplex upon peptide binding in potassium
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DOI: 10.1039/d2ra00535b
Abstract: We selected the G-quadruplex motif located in the nuclease-hypersensitive elements (NHE) III1 region of the c-Myc promoter and for the first time performed its interaction studies with a designed peptide (QW10). Our CD results showed… read more here.
Keywords: peptide binding; myc promoter; significant structural; myc ... See more keywords
Binding symmetric porphyrins to c-MYC promoter Pu24I G-quadruplex: toward more specific ligand recognition by flanking bases
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DOI: 10.1039/d3nj00956d
Abstract: Stabilization of G-quadruplexes formed in the promotor regions of oncogenes with small molecules is recognized as a convenient method to control oncogenes' overexpression in cancer cells. Due to a huge... read more here.
Keywords: symmetric porphyrins; promoter pu24i; pu24i quadruplex; porphyrins myc ... See more keywords
Hinge like domain motion facilitates human RBMS1 protein binding to proto-oncogene c-myc promoter
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DOI: 10.1093/nar/gkab363
Abstract: Abstract DNA binding proteins recognize DNA specifically or non-specifically using direct and indirect readout mechanisms like sliding, hopping, and diffusion. However, a common difficulty in explicitly elucidating any particular mechanism of site-specific DNA-protein recognition is… read more here.
Keywords: protein; proto oncogene; rbms1 protein; human rbms1 ... See more keywords
Rational design of small-molecules to recognize G-quadruplexes of c-MYC promoter and telomere and the evaluation of their in vivo antitumor activity against breast cancer
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DOI: 10.1093/nar/gkac090
Abstract: Abstract DNA G4-structures from human c-MYC promoter and telomere are considered as important drug targets; however, the developing of small-molecule-based fluorescent binding ligands that are highly selective in targeting these G4-structures over other types of… read more here.
Keywords: promoter; promoter telomere; antitumor activity; myc promoter ... See more keywords
Topoisomerase 1 inhibits MYC promoter activity by inducing G-quadruplex formation
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DOI: 10.1093/nar/gkac482
Abstract: Abstract We have investigated the function of human topoisomerase 1 (TOP1) in regulation of G-quadruplex (G4) formation in the Pu27 region of the MYC P1 promoter. Pu27 is among the best characterized G4 forming sequences… read more here.
Keywords: promoter; myc promoter; pu27; formation ... See more keywords
Overexpression of c-MYC Promoter Binding Protein-1 Enhances Proliferation and Glucose Metabolism of Melanoma Cells Lines
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DOI: 10.21873/anticanres.16420
Abstract: Background/Aim: c-MYC promoter binding protein (MBP-1) is a product of alternatively translated mRNA encoding alpha-enolase (ENO1). In contrast to ENO1, MBP-1 possesses no enzymatic activity but acts as a transcriptional repressor of c-MYC. Ectopic over-expression… read more here.
Keywords: cell; melanoma; proliferation; myc promoter ... See more keywords