A Selective Small‐Molecule c‐Myc Degrader Potently Regresses Lethal c‐Myc Overexpressing Tumors
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202104344
Abstract: MYC oncogene is involved in the majority of human cancers and is often associated with poor outcomes, rendering it an extraordinarily desirable target, but therapeutic targeting of c‐Myc protein has been a challenge for >30… read more here.
Keywords: potently regresses; overexpressing tumors; lethal myc; myc ... See more keywords
Identifying and Validating MYC:Protein Interactors in Pursuit of Novel Anti-MYC Therapies.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1476-1_4
Abstract: By identifying MYC protein-protein interactors, we aim to gain a deeper mechanistic understanding of MYC as a regulator of gene transcription and potent oncoprotein. This information can then be used to devise strategies for disrupting… read more here.
Keywords: protein; identifying validating; myc protein; protein interactors ... See more keywords
Stabilization of the c-Myc Protein by CAMKIIγ Promotes T Cell Lymphoma.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer cell"
DOI: 10.1016/j.ccell.2017.06.001
Abstract: Although high c-Myc protein expression is observed alongside MYC amplification in some cancers, in most cases protein overexpression occurs in the absence of gene amplification, e.g., T cell lymphoma (TCL). Here, Ca2+/calmodulin-dependent protein kinase II γ… read more here.
Keywords: protein; myc protein; stabilization myc; camkii ... See more keywords
MYC protein stability is negatively regulated by BRD4
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1919507117
Abstract: Significance Dysregulation of MYC protein levels is associated with most human cancers. MYC is regulated by both transcription and protein stability. BRD4, a driver of oncogenesis that activates Myc transcription, is being investigated as a… read more here.
Keywords: protein; protein stability; transcription; myc protein ... See more keywords
Low expression of c-Myc protein predicts poor outcomes in patients with hepatocellular carcinoma after resection
Sign Up to like & getrecommendations! Published in 2018 at "BMC Cancer"
DOI: 10.1186/s12885-018-4379-5
Abstract: BackgroundEmbryonic Liver Fodrin (ELF) is an adaptor protein of transforming growth factor (TGF-β) signaling cascade. Disruption of ELF results in mislocalization of Smad3 and Smad4, leading to compromised TGF-β signaling. c-Myc is an important oncogenic… read more here.
Keywords: outcomes patients; expression; expression myc; myc ... See more keywords
SLC35B4 Stabilizes c-MYC Protein by O-GlcNAcylation in HCC
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.851089
Abstract: UDP-GlcNAc is a sugar substrate necessary for the O-GlcNAcylation of proteins. SLC35B4 is one of the nucleotide sugar transporters that transport UDP-GlcNAc and UDP-xylose into the endoplasmic reticulum and Golgi apparatus for glycosylation. The roles… read more here.
Keywords: myc protein; glcnacylation; hcc; slc35b4 stabilizes ... See more keywords
Platycodin-D exerts its anti-cancer effect by promoting c-Myc protein ubiquitination and degradation in gastric cancer
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1138658
Abstract: Platycodin D (PD) is a triterpene saponin extracted from the root of Platycodon grandiflorum. It has been reported to exhibit multiple pharmacological and biological properties. There is substantial evidence to support that PD displays a… read more here.
Keywords: cell; anti cancer; gastric cancer; myc protein ... See more keywords
Small Molecule 20S Proteasome Enhancer Regulates MYC Protein Stability and Exhibits Antitumor Activity in Multiple Myeloma
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10050938
Abstract: Despite the addition of several new agents to the armamentarium for the treatment of multiple myeloma (MM) in the last decade and improvements in outcomes, the refractory and relapsing disease continues to take a great… read more here.
Keywords: 20s proteasome; small molecule; myc protein; multiple myeloma ... See more keywords