MYC Regulation of D2HGDH and L2HGDH Influences the Epigenome and Epitranscriptome.
Sign Up to like & getrecommendations! Published in 2020 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2020.02.002
Abstract: Mitochondrial D2HGDH and L2HGDH catalyze the oxidation of D-2-HG and L-2-HG, respectively, into αKG. This contributes to cellular homeostasis in part by modulating the activity of αKG-dependent dioxygenases. Signals that control the expression/activity of D2HGDH/L2HGDH… read more here.
Keywords: d2hgdh; myc regulation; epigenome epitranscriptome; d2hgdh l2hgdh ... See more keywords
Myc Regulation of a Mitochondrial Trafficking Network Mediates Tumor Cell Invasion and Metastasis
Sign Up to like & getrecommendations! Published in 2019 at "Molecular and Cellular Biology"
DOI: 10.1128/mcb.00109-19
Abstract: The Myc gene is a universal oncogene that promotes aggressive cancer, but its role in metastasis has remained elusive. Here, we show that Myc transcriptionally controls a gene network of subcellular mitochondrial trafficking that includes… read more here.
Keywords: metastasis; cell invasion; myc regulation; network ... See more keywords