Design, Synthesis, and Evaluation of New Sugar-Substituted Imidazole Derivatives as Selective c-MYC Transcription Repressors Targeting the Promoter G-Quadruplex.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00467
Abstract: c-MYC is a key driver of tumorigenesis. Repressing the transcription of c-MYC by stabilizing the G-quadruplex (G4) structure with small molecules is a potential strategy for cancer therapy. Herein, we designed and synthesized 49 new… read more here.
Keywords: myc transcription; transcription; design synthesis; targeting promoter ... See more keywords
New substituted quinoxalines inhibit triple-negative breast cancer by specifically downregulating the c-MYC transcription
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkz835
Abstract: Abstract Conventional chemotherapy remains the primary treatment option for triple-negative breast cancer (TNBC). However, the current chemotherapeutic drugs have limited effects on TNBC, and often lead to serious side effects as well as drug resistance.… read more here.
Keywords: cancer; myc transcription; tnbc; triple negative ... See more keywords
Jasmonate-Related MYC Transcription Factors Are Functionally Conserved in Marchantia polymorpha
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DOI: 10.1105/tpc.18.00974
Abstract: Despite 450 million years of independent evolution, MYC transcription factors that regulate jasmonate responses are functionally conserved between bryophytes and eudicots. The lipid-derived phytohormone jasmonoyl-isoleucine regulates plant immunity, growth and development in vascular plants by… read more here.
Keywords: myc transcription; functionally conserved; jasmonate; transcription factors ... See more keywords
Dual Inhibition of Myc Transcription and PI3K Activity Effectively Targets Colorectal Cancer Stem Cells
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DOI: 10.3390/cancers14030673
Abstract: Simple Summary Compelling evidence has shown that cancer stem cells (CSCs) are responsible for high resistance to conventional anti-cancer therapies. Here, we demonstrate that the tumor microenvironment protects CR-CSCs from EGFR/HER2, BRAF and PI3K targeting,… read more here.
Keywords: pi3k; myc transcription; myc; activity ... See more keywords
Jasmonic Acid-Dependent MYC Transcription Factors Bind to a Tandem G-Box Motif in the YUCCA8 and YUCCA9 Promoters to Regulate Biotic Stress Responses
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22189768
Abstract: The indole-3-pyruvic acid pathway is the main route for auxin biosynthesis in higher plants. Tryptophan aminotransferases (TAA1/TAR) and members of the YUCCA family of flavin-containing monooxygenases catalyze the conversion of l-tryptophan via indole-3-pyruvic acid to… read more here.
Keywords: myc transcription; transcription; jasmonic acid; tandem box ... See more keywords
Methylation-mediated LINC00261 suppresses pancreatic cancer progression by epigenetically inhibiting c-Myc transcription
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DOI: 10.7150/thno.44278
Abstract: Background: Due to the limitations of strategies for its early diagnosis and treatment, pancreatic cancer (PC) remains a substantial human health threat. We previously discovered a methylation-mediated lncRNA, LINC00261, which is downregulated in PC tissues.… read more here.
Keywords: myc transcription; methylation; mediated linc00261; pancreatic cancer ... See more keywords