Inhibiting DHN- and DOPA-melanin biosynthesis pathway increased the therapeutic value of itraconazole in Madurella mycetomatis infected Galleria mellonella
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DOI: 10.1093/mmy/myac003
Abstract: Abstract Eumycetoma is a neglected tropical disease, and Madurella mycetomatis, the most common causative agent of this disease forms black grains in hosts. Melanin was discovered to be one of the constituents in grains. Melanins… read more here.
Keywords: dopa melanin; mycetomatis; melanin; melanin biosynthesis ... See more keywords
Pyomelanin Secretion in Madurella mycetomatis Interferes with Spectrophotometric Endpoint Reading Using the Sensititre YeastOne alamarBlue Assay but Not with Visual Endpoint Reading
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DOI: 10.1128/aac.01532-19
Abstract: The use of the Sensititre YeastOne YO10 alamarBlue assay for the in vitro susceptibility testing of Madurella mycetomatis was evaluated in M. mycetomatis isolates with and without pyomelanin secretion. Pyomelanin secretion did not influence visual… read more here.
Keywords: pyomelanin secretion; endpoint; sensititre yeastone; endpoint reading ... See more keywords
The synthetic synergistic cinnamon oil CIN-102 is active against Madurella mycetomatis, the most common causative agent of mycetoma
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0009488
Abstract: Mycetoma is a devastating neglected tropical infection of the subcutaneous tissue and most commonly caused by the fungus Madurella mycetomatis. Treatment of mycetoma consists of a combination of a long term antifungal treatment with itraconazole… read more here.
Keywords: madurella mycetomatis; mycetoma; cin 102; mycetomatis ... See more keywords
Genomics and metagenomics of Madurella mycetomatis, a causative agent of black grain mycetoma in Sudan
Sign Up to like & getrecommendations! Published in 2022 at "PLOS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0010787
Abstract: Madurella mycetomatis is one of the main causative agents of mycetoma, a debilitating neglected tropical disease. Improved understanding of the genomic diversity of the fungal and bacterial causes of mycetoma is essential to advances in… read more here.
Keywords: mycetomatis; genomics metagenomics; metagenomics madurella; madurella mycetomatis ... See more keywords