Abstract 3840: High-resolution structural insights into targeting the MYC oncogene G-quadruplex with the quinoline derivative PEQ
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DOI: 10.1158/1538-7445.am2023-3840
Abstract: The transcription of the MYC oncogene, a central player of oncogenesis, is strongly controlled by DNA G-quadruplexes in its promoter region (MycG4). Stabilization of MycG4 with small molecules downregulates MYC expression and has devastating effects… read more here.
Keywords: mycg4; peq; high resolution; cancer ... See more keywords