MYCN amplified neuroblastoma requires the mRNA translation regulator eEF2 kinase to adapt to nutrient deprivation
Sign Up to like & getrecommendations! Published in 2017 at "Cell Death and Differentiation"
DOI: 10.1038/cdd.2017.79
Abstract: MYC family proteins are implicated in many human cancers, but their therapeutic targeting has proven challenging. MYCN amplification in childhood neuroblastoma (NB) is associated with aggressive disease and high mortality. Novel and effective therapeutic strategies… read more here.
Keywords: kinase; mycn; mycn amplified; nutrient deprivation ... See more keywords
Glycine decarboxylase is a transcriptional target of MYCN required for neuroblastoma cell proliferation and tumorigenicity
Sign Up to like & getrecommendations! Published in 2019 at "Oncogene"
DOI: 10.1038/s41388-019-0967-3
Abstract: Genomic amplification of the oncogene MYCN is a major driver in the development of high-risk neuroblastoma, a pediatric cancer with poor prognosis. Given the challenge in targeting MYCN directly for therapy, we sought to identify… read more here.
Keywords: gldc; transcriptional target; mycn; proliferation ... See more keywords
Development of an osteosarcoma model with MYCN amplification and TP53 mutation in hiPS cell‐derived neural crest cells
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Science"
DOI: 10.1111/cas.15730
Abstract: Mesenchymal stem cell‐ or osteoblast‐derived osteosarcoma is the most common malignant bone tumor. Its highly metastatic malignant phenotypes, which are often associated with a poor prognosis, have been correlated with the modulation of TP53‐ and… read more here.
Keywords: derived neural; neural crest; crest cells; tp53 ... See more keywords
The super elongation complex drives transcriptional addiction in MYCN-amplified neuroblastoma
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.adf0005
Abstract: MYCN amplification in neuroblastoma leads to aberrant expression of MYCN oncoprotein, which binds active genes promoting transcriptional amplification. Yet, how MYCN coordinates transcription elongation to meet productive transcriptional amplification and which elongation machinery represents MYCN-driven… read more here.
Keywords: mycn amplified; elongation; transcription elongation; super elongation ... See more keywords
MYCN amplification and International Neuroblastoma Risk Group stratification on fine-needle aspiration biopsy and their correlation to survival in neuroblastoma
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Pathology"
DOI: 10.1136/jclinpath-2022-208177
Abstract: Aims Risk stratification as per the International Neuroblastoma Risk Group (INRG) stratification is important for management of neuroblastoma. INRG incorporates various parameters including histological category as per the International Neuroblastoma Pathology Classification (INPC) and MYCN… read more here.
Keywords: international neuroblastoma; stratification; pathology; risk ... See more keywords
Neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene or MYCN gene
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Clinical Pathology"
DOI: 10.1136/jcp-2022-208476
Abstract: The MYCN gene belongs to the MYC family of transcription factors. Amplification of MYCN, first discovered in neuroblastoma cells, ushered in the era of cancer genomics. The MYCN gene and MYCN protein are extensively studied… read more here.
Keywords: mycn gene; myc avian; mycn; derived myc ... See more keywords
Network Modeling of microRNA-mRNA Interactions in Neuroblastoma Tumorigenesis Identifies miR-204 as a Direct Inhibitor of MYCN.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer research"
DOI: 10.1158/0008-5472.can-17-3034
Abstract: Neuroblastoma is a pediatric cancer of the sympathetic nervous system where MYCN amplification is a key indicator of poor prognosis. However, mechanisms by which MYCN promotes neuroblastoma tumorigenesis are not fully understood. In this study,… read more here.
Keywords: network; mirna; mycn; mir 204 ... See more keywords
Drugging the “Undruggable” MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Research"
DOI: 10.1158/0008-5472.can-20-3108
Abstract: Effective treatment of pediatric solid tumors has been hampered by the predominance of currently “undruggable” driver transcription factors. Improving outcomes while decreasing the toxicity of treatment necessitates the development of novel agents that can directly… read more here.
Keywords: transcription; undruggable mycn; transcription factor; mycn ... See more keywords
Abstract 3036: ALK protein expression and its prognostic significance in MYCN non amplified neuroblastoma
Sign Up to like & getrecommendations! Published in 2021 at "Tumor Biology"
DOI: 10.1158/1538-7445.am2021-3036
Abstract: Anaplastic lymphoma kinase (ALK) point mutations (within the kinase domain), gene amplification and protein overexpression are identified (8-14%) both in familial and sporadic high-risk neuroblastoma (HR-NB). ALK mutations are much more frequent at time of… read more here.
Keywords: expression; mycn non; non amplified; mycn ... See more keywords
Abstract 3536: Role of Myc family proteins in fusion-positive rhabdomyosarcoma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3536
Abstract: Fusion-positive rhabdomyosarcoma (FP RMS) is an aggressive pediatric malignancy characterized by the presence of a PAX3-FOXO1 (P3F) or PAX7-FOXO1 fusion gene. Previous RNA expression studies have shown that these FP RMS tumors also express high… read more here.
Keywords: dbt; expression; myc; ip3f ... See more keywords
Upregulated heme biosynthesis, an exploitable vulnerability in MYCN-driven leukemogenesis.
Sign Up to like & getrecommendations! Published in 2017 at "JCI insight"
DOI: 10.1172/jci.insight.92409
Abstract: The increased heme biosynthesis long observed in leukemia was previously of unknown significance. Heme, synthesized from porphyrin precursors, plays a central role in oxygen metabolism and mitochondrial function, yet little is known about its role… read more here.
Keywords: heme; heme biosynthesis; leukemogenesis; mycn ... See more keywords