MYCN amplified neuroblastoma requires the mRNA translation regulator eEF2 kinase to adapt to nutrient deprivation
Sign Up to like & getrecommendations! Published in 2017 at "Cell Death and Differentiation"
DOI: 10.1038/cdd.2017.79
Abstract: MYC family proteins are implicated in many human cancers, but their therapeutic targeting has proven challenging. MYCN amplification in childhood neuroblastoma (NB) is associated with aggressive disease and high mortality. Novel and effective therapeutic strategies… read more here.
Keywords: kinase; mycn; mycn amplified; nutrient deprivation ... See more keywords
Macrophage infiltration promotes regrowth in MYCN-amplified neuroblastoma after chemotherapy
Sign Up to like & getrecommendations! Published in 2023 at "Oncoimmunology"
DOI: 10.1080/2162402x.2023.2184130
Abstract: ABSTRACT Despite aggressive treatment, the 5-year event-free survival rate for children with high-risk neuroblastoma is read more here.
Keywords: infiltration; mycn amplified; treatment; tumor ... See more keywords
MBRS-57. TARGETING METABOLIC ADAPTATION IN MYC/MYCN AMPLIFIED PEDIATRIC MEDULLOBLASTOMA AND NEUROBLASTOMA
Sign Up to like & getrecommendations! Published in 2018 at "Neuro-oncology"
DOI: 10.1093/neuonc/noy059.501
Abstract: BACKGROUND The MYC oncogenes contribute to more than 50% of all human cancers, but their therapeutic targeting has proven challenging. MYC/MYCN amplification in childhood medulloblastoma (MB) and neuroblastoma (NB) determine aggressive disease and high mortality,… read more here.
Keywords: medulloblastoma neuroblastoma; myc mycn; mycn amplified; adaptation myc ... See more keywords
Activation of cell migration via morphological changes in focal adhesions depends on shear stress in MYCN-amplified neuroblastoma cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Royal Society Interface"
DOI: 10.1098/rsif.2018.0934
Abstract: Neuroblastoma is the most common solid tumour of childhood, and it metastasizes to distant organs. However, the mechanism of metastasis, which generally depends on the cell motility of the neuroblastoma, remains unclear. In many solid… read more here.
Keywords: cell; mycn amplified; shear stress; cell motility ... See more keywords
TAF1D promotes proliferation by transcriptionally activating G2/M phase-related genes in MYCN-amplified neuroblastoma.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer science"
DOI: 10.1111/cas.15815
Abstract: High-risk neuroblastoma (HR-NB) is an aggressive childhood cancer that responds poorly to currently available therapies and is associated with only about a 50% 5-year survival rate. MYCN amplification is a critical driver of these aggressive… read more here.
Keywords: cell; cell cycle; mycn amplified; proliferation ... See more keywords
The super elongation complex drives transcriptional addiction in MYCN-amplified neuroblastoma
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.adf0005
Abstract: MYCN amplification in neuroblastoma leads to aberrant expression of MYCN oncoprotein, which binds active genes promoting transcriptional amplification. Yet, how MYCN coordinates transcription elongation to meet productive transcriptional amplification and which elongation machinery represents MYCN-driven… read more here.
Keywords: mycn amplified; elongation; transcription elongation; super elongation ... See more keywords
Druggable epigenetic suppression of interferon-induced chemokine expression linked to MYCN amplification in neuroblastoma
Sign Up to like & getrecommendations! Published in 2021 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2020-001335
Abstract: Background Amplification of the MYCN oncogene is a molecular hallmark of aggressive neuroblastoma (NB), a childhood cancer of the sympathetic nervous system. There is evidence that MYCN promotes a non-inflamed and T-cell infiltration-poor (‘cold’) tumor… read more here.
Keywords: neuroblastoma; interferon; chemokine expression; expression ... See more keywords
Serine-Glycine-One-Carbon Metabolism: The Hidden Achilles Heel of MYCN-Amplified Neuroblastoma?
Sign Up to like & getrecommendations! Published in 2019 at "Cancer research"
DOI: 10.1158/0008-5472.can-19-1816
Abstract: In this issue of Cancer Research, Xia and colleagues show that MYC-induced metabolic reprograming results in dependency on the serine-glycine-one-carbon (SGOC) metabolic pathway in neuroblastoma. This occurs through MYCN and ATF4 activation of the SGOC… read more here.
Keywords: serine glycine; one carbon; mycn amplified; glycine one ... See more keywords
Abstract 2062: Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-2062
Abstract: Childhood neuroblastomas with MYCN gene amplification form a particularly high-risk subset of this disease and are difficult to treat effectively. This has focused attention on tumor-specific gene dependencies that reflect important pathways in tumorigenesis, and… read more here.
Keywords: regulatory circuitry; gene dependencies; mycn amplified; amplified neuroblastoma ... See more keywords
Abstract 3521: Glutamine metabolic inhibition synergizes with L-asparaginase in MYCN-amplified neuroblastoma
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-3521
Abstract: Neuroblastoma is the most common extracranial solid tumor in children. Though it accounts for about 10% of pediatric cancers, it is disproportionately responsible for 15% of pediatric cancer deaths. MYCN is amplified in 20% of… read more here.
Keywords: mycn amplified; amplified neuroblastoma; cancer; glutamine ... See more keywords
The Killing of Human Neuroblastoma Cells by the Small Molecule JQ1 Occurs in a p53-Dependent Manner
Sign Up to like & getrecommendations! Published in 2020 at "Anti-Cancer Agents in Medicinal Chemistry"
DOI: 10.2174/1871520620666200424123834
Abstract: Background MYCN amplification is a prognostic biomarker associated with poor prognosis of neuroblastoma in children. The overall survival of children with MYCN-amplified neuroblastoma has only marginally improved within the last 20 years. The Bromodomain and… read more here.
Keywords: mycn; jq1; mycn amplified; neuroblastoma cells ... See more keywords