ZAR1 knockdown promotes the differentiation of human neuroblastoma cells by suppression of MYCN expression
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DOI: 10.1007/s12032-017-0999-x
Abstract: Although DNA hypermethylation at non-promoter region of the Zygote arrest 1 (ZAR1) gene has been observed in many types of tumor, including neuroblastoma (NB), the role of this gene in tumor development and/or progression is… read more here.
Keywords: mycn expression; zar1; expression; depleted cells ... See more keywords
MYCN expression induces replication stress and sensitivity to PARP inhibition in neuroblastoma
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DOI: 10.18632/oncotarget.27329
Abstract: This study investigates the influence expression of the MYCN oncogene has on the DNA damage response, replication fork progression and sensitivity to PARP inhibition in neuroblastoma. In a panel of neuroblastoma cell lines, MYCN amplification… read more here.
Keywords: mycn expression; parp inhibition; replication; inhibition ... See more keywords