Abstract 3036: ALK protein expression and its prognostic significance in MYCN non amplified neuroblastoma
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DOI: 10.1158/1538-7445.am2021-3036
Abstract: Anaplastic lymphoma kinase (ALK) point mutations (within the kinase domain), gene amplification and protein overexpression are identified (8-14%) both in familial and sporadic high-risk neuroblastoma (HR-NB). ALK mutations are much more frequent at time of… read more here.
Keywords: expression; mycn non; non amplified; mycn ... See more keywords
Prominent Staining of MYCN Immunohistochemistry Predicts a Poor Prognosis in MYCN Non-Amplified Neuroblastoma
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DOI: 10.1177/10935266231151316
Abstract: Background: MYCN gene amplification is a powerful indicator of poor prognosis of neuroblastoma patients. However, MYCN non-amplified patients still showed heterogeneity in survival outcome. This study aimed to investigate the prognostic role of MYCN immunohistochemistry… read more here.
Keywords: amplification; poor prognosis; staining mycn; mycn ... See more keywords
Low Expression of IL-15 and NKT in Tumor Microenvironment Predicts Poor Outcome of MYCN-Non-Amplified Neuroblastoma
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DOI: 10.3390/jpm11020122
Abstract: Immune tumor microenvironment (TME) in neuroblastoma (NBL) contributes to tumor behavior and treatment response. T cells and natural killer (NK) cells have been shown to play important roles in the neuroblastoma TME. However, few reports… read more here.
Keywords: non amplified; nkt; expression; mycn non ... See more keywords