Photoinactivation of mycobacteria to combat infection diseases: current state and perspectives
Sign Up to like & getrecommendations! Published in 2021 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-021-11349-0
Abstract: Abstract The spread of multi-drug-resistant bacterial strains causing serious infectious diseases dictates the development of new approaches to combat these diseases. In addition to drug resistance, the important causative agent of tuberculosis (Mycobacterium tuberculosis (Mtb))… read more here.
Keywords: combat; photoinactivation mycobacteria; drug; tuberculosis ... See more keywords
Protein tyrosine kinase A modulates intracellular survival of mycobacteria through Galectin 3.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.03.075
Abstract: Mycobacterium tuberculosis (MTB) is a successful pathogen which increases persistence inside the host macrophage by subverting its defence mechanism. Mycobacteria regulate the pathogenesis and intracellular survival by controlling its interaction with host protein(s). Galectin 3… read more here.
Keywords: intracellular survival; galectin; protein tyrosine; mycobacteria ... See more keywords
Mycobacterium avium complex infected cells promote growth of the pathogen Pseudomonas aeruginosa.
Sign Up to like & getrecommendations! Published in 2022 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2022.105549
Abstract: Bronchiectasis is considered a consequence of the neutrophilic inflammatory response to infection. Mycobacterial infections, mainly from the Mycobacterium avium complex and M. abscessus, have been inextricably linked to bronchiectasis development. The most important pathogen that… read more here.
Keywords: pathogen; avium complex; mycobacterium avium; avium ... See more keywords
Evaluation of nitroxyl donors' effect on mycobacteria.
Sign Up to like & getrecommendations! Published in 2018 at "Tuberculosis"
DOI: 10.1016/j.tube.2018.01.006
Abstract: Nitroxyl (HNO) is a highly elusive and reactive molecule. Nitroxyl biological effects and pharmacological potential are becoming increasingly relevant. Mycobacterium tuberculosis infection needs new and more efficient drugs. Reactive Nitrogen and Oxygen Species (RNOS) are… read more here.
Keywords: evaluation nitroxyl; effect; tuberculosis; mycobacteria ... See more keywords
Synthesis and Characterization of Phenylalanine Amides Active against Mycobacterium abscessus and Other Mycobacteria.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.3c00009
Abstract: Nα-2-thiophenoyl-d-phenylalanine-2-morpholinoanilide [MMV688845, Pathogen Box; Medicines for Malaria Venture; IUPAC: (2R)-N-(1-((2-morpholinophenyl)amino)-1-oxo-3-phenylpropan-2-yl)thiophene-2-carboxamide)] is a hit compound, which shows activity against Mycobacterium abscessus (MIC90 6.25-12.5 μM) and other mycobacteria. This work describes derivatization of MMV688845 by introducing a… read more here.
Keywords: phenylalanine; mycobacterium abscessus; synthesis; mycobacterium ... See more keywords
Pulmonary Tuberculosis Conversion Documented by Microscopic Staining for Detection of Dynamic, Dormant, and Dead Mycobacteria (DDD Staining)
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Microbiology"
DOI: 10.1128/jcm.01108-18
Abstract: Detecting the infectiousness of Mycobacterium tuberculosis mycobacteria in the sputum specimens collected from patients with pulmonary tuberculosis remains cumbersome.…. read more here.
Keywords: pulmonary tuberculosis; documented microscopic; conversion documented; tuberculosis ... See more keywords
Cellular and Structural Basis of Synthesis of the Unique Intermediate Dehydro-F420-0 in Mycobacteria
Sign Up to like & getrecommendations! Published in 2020 at "mSystems"
DOI: 10.1128/msystems.00389-20
Abstract: Mycobacteria are major environmental microorganisms and cause many significant diseases, including tuberculosis. Mycobacteria make an unusual vitamin-like compound, F420, and use it to both persist during stress and resist antibiotic treatment. Understanding how mycobacteria make… read more here.
Keywords: f420; mycobacteria make; tuberculosis; mycobacteria ... See more keywords
FDA-Approved Amoxapine Effectively Promotes Macrophage Control of Mycobacteria by Inducing Autophagy
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.02509-22
Abstract: The emergence and spread of multidrug-resistant (MDR) and extensive drug-resistant (XDR) TB urges the development of new therapeutics. One promising approach to combat drug resistance is targeting host factors necessary for the bacteria to survive… read more here.
Keywords: development; mycobacteria; intracellular killing; host ... See more keywords
Fragment-Based Drug Discovery against Mycobacteria: The Success and Challenges
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231810669
Abstract: The emergence of drug-resistant mycobacteria, including Mycobacterium tuberculosis (Mtb) and non-tuberculous mycobacteria (NTM), poses an increasing global threat that urgently demands the development of new potent anti-mycobacterial drugs. One of the approaches toward the identification… read more here.
Keywords: fragment based; drug discovery; mycobacteria; based drug ... See more keywords