Impact of individual-level factors on Ex vivo mycobacterial growth inhibition: Associations of immune cell phenotype, cytomegalovirus-specific response and sex with immunity following BCG vaccination in humans.
Sign Up to like & getrecommendations! Published in 2019 at "Tuberculosis"
DOI: 10.1016/j.tube.2019.101876
Abstract: Understanding factors associated with varying efficacy of Bacillus Calmette-Guérin (BCG) would aid the development of improved vaccines against tuberculosis (TB). In addition, investigation of individual-level factors affecting mycobacterial-specific immune responses could provide insight into confounders… read more here.
Keywords: bcg vaccination; cell; growth inhibition; mycobacterial growth ... See more keywords
Cell-autonomous targeting of arabinogalactan by host immune factors inhibits mycobacterial growth
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DOI: 10.1101/2023.10.05.561003
Abstract: Deeper understanding of the crosstalk between host cells and Mycobacterium tuberculosis (Mtb) provides crucial guidelines for the rational design of novel intervention strategies against tuberculosis (TB). Mycobacteria possess a unique complex cell wall with arabinogalactan… read more here.
Keywords: mycobacterial growth; galectin; cell autonomous; host ... See more keywords
Whole Blood Mycobacterial Growth Assays for Assessing Human Tuberculosis Susceptibility: A Systematic Review and Meta-Analysis
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DOI: 10.3389/fimmu.2021.641082
Abstract: Background Whole blood mycobacterial growth assays (WBMGA) quantify mycobacterial growth in fresh blood samples and may have potential for assessing tuberculosis vaccines and identifying individuals at risk of tuberculosis. We evaluated the evidence for the… read more here.
Keywords: tuberculosis susceptibility; susceptibility; wbmga results; mycobacterial growth ... See more keywords
miR-107-enriched exosomes promote ROS/wnt/autophagy, inhibit intracellular mycobacterial growth and attenuate lung infection
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2025.1567167
Abstract: Exosomes, known as small membrane vesicles of endocytic origin produced by most cell types, exist in a variety of body fluids including plasma. The roles of exosomes in immune responses against Mycobacteria tuberculosis (Mtb) infection… read more here.
Keywords: mycobacterial growth; mir 107; infection; 107 enriched ... See more keywords