Heterogeneity of ROS levels in antibiotic-exposed mycobacterial subpopulations confers differential susceptibility.
Sign Up to like & getrecommendations! Published in 2019 at "Microbiology"
DOI: 10.1099/mic.0.000797
Abstract: Phenotypically heterogeneous but genetically identical mycobacterial subpopulations exist in in vitro cultures, in vitro-infected macrophages, infected animal models and tuberculosis patients. In this regard, we recently reported the presence of two subpopulations of cells, which… read more here.
Keywords: susceptibility; differential susceptibility; mycobacterial subpopulations; antibiotic exposed ... See more keywords
Growth and division mechanisms by which genetic resisters emerge from the rifampicin-surviving population of differentially antibiotic-susceptible mycobacterial subpopulations
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Mycobacteriology"
DOI: 10.4103/ijmy.ijmy_88_22
Abstract: Background: We recently reported the de novo emergence of unusually high numbers of antibiotic resisters from the in vitro cultures of Mycobacterium tuberculosis and Mycobacterium smegmatis surviving in the presence of minimum bactericidal concentration (MBC)… read more here.
Keywords: growth division; population; rifampicin; mycobacterial subpopulations ... See more keywords