Outbreak of Cosmetology-Acquired Mycobacterium abscessus Skin Infection.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA dermatology"
DOI: 10.1001/jamadermatol.2022.6385
Abstract: This case report describes numerous warm, red, edematous, tender, fluctuant, and purulent draining nodules on the abdomen following a catgut implant procedure. read more here.
Keywords: outbreak cosmetology; mycobacterium abscessus; acquired mycobacterium; cosmetology ... See more keywords
Biochemical, structural, and functional studies reveal that MAB_4324c from Mycobacterium abscessus is an active tandem repeat N-acetyltransferase.
Sign Up to like & getrecommendations! Published in 2022 at "FEBS letters"
DOI: 10.1002/1873-3468.14360
Abstract: Mycobacterium abscessus is a pathogenic non-tuberculous mycobacterium that possesses an intrinsic drug-resistance profile. Several N-acetyltransferases mediate drug resistance and/or participate in M. abscessus virulence. Mining the M. abscessus genome has revealed genes encoding additional N-acetyltransferases… read more here.
Keywords: mab 4324c; mycobacterium abscessus; abscessus; biochemical structural ... See more keywords
Structure‐Based Design and Synthesis of Piperidinol‐Containing Molecules as New Mycobacterium abscessus Inhibitors
Sign Up to like & getrecommendations! Published in 2020 at "ChemistryOpen"
DOI: 10.1002/open.202000042
Abstract: Abstract Non‐tuberculous mycobacterium (NTM) infections, such as those caused by Mycobacterium abscessus, are increasing globally. Due to their intrinsic drug resistance, M. abscessus pulmonary infections are often difficult to cure using standard chemotherapy. We previously… read more here.
Keywords: mycobacterium; piperidinol; abscessus; structure based ... See more keywords
Effect of amikacin on cell wall glycopeptidolipid synthesis in Mycobacterium abscessus
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Microbiology"
DOI: 10.1007/s12275-017-6503-7
Abstract: Cultivation of the smooth colony Mycobacterium abscessus at the sub-minimum inhibitory concentration (MIC) of amikacin changed its growth pattern including its colony morphology (smooth to rough) and cell arrangement (dispersed to cord formation). In addition,… read more here.
Keywords: cell wall; amikacin; abscessus; mycobacterium abscessus ... See more keywords
Treatment of Mycobacterium abscessus Pulmonary Disease.
Sign Up to like & getrecommendations! Published in 2021 at "Chest"
DOI: 10.1016/j.chest.2021.07.035
Abstract: Mycobacterium abscessus is the second most common nontuberculous mycobacterial lung disease pathogen and comprises three subspecies, abscessus, massiliense and bolletii. Subspecies identification is critical for disease management as subspecies abscessus and bolletii have an inducible… read more here.
Keywords: treatment; disease; abscessus; macrolide resistance ... See more keywords
In vitro activity between linezolid and other antimicrobial agents against Mycobacterium abscessus complex.
Sign Up to like & getrecommendations! Published in 2018 at "Diagnostic microbiology and infectious disease"
DOI: 10.1016/j.diagmicrobio.2017.09.013
Abstract: Linezolid (LZD) serves as an effective option in the treatment of Mycobacterium abscessus complex (MABC) infection. Unfortunately, the combined activities of LZD with other antimicrobial agents against MABC have not been evaluated systemically. In this… read more here.
Keywords: abscessus complex; antimicrobial agents; amk; lzd ... See more keywords
Antimicrobial susceptibility profiles of Mycobacterium abscessus complex isolated from respiratory specimens in Shanghai, China.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of global antimicrobial resistance"
DOI: 10.1016/j.jgar.2021.02.024
Abstract: OBJECTIVES To compare the antibiotic susceptibility profiles of Mycobacterium abscessus complex (MABC) and investigate the relationship between susceptibility profiles and genetic mechanism of macrolides resistance. METHODS Over 200 isolates collected from respiratory specimens between 2014… read more here.
Keywords: susceptibility; profiles mycobacterium; abscessus complex; abscessus ... See more keywords
Case report on pulmonary disease due to coinfection of Mycobacterium tuberculosis and Mycobacterium abscessus: Difficulty in diagnosis
Sign Up to like & getrecommendations! Published in 2017 at "Respiratory Medicine Case Reports"
DOI: 10.1016/j.rmcr.2017.01.011
Abstract: Mycobacterium abscessus, which is ubiquitous environmental organism, is more likely to cause pulmonary infection in the presence underlying lung disease and immunosuppression. We report a case of pulmonary disease due to coinfection of Mycobacterium tuberculosis… read more here.
Keywords: mycobacterium; abscessus; case; pulmonary disease ... See more keywords
STAT3 gain-of-function mutation in a patient with pulmonary Mycobacterium abscessus infection
Sign Up to like & getrecommendations! Published in 2020 at "Respiratory Medicine Case Reports"
DOI: 10.1016/j.rmcr.2020.101125
Abstract: Background Signal transducer and activator of transcription 3 (STAT3) is a transcription factor involved in cellular proliferation, apoptosis, and differentiation. Mutations in the STAT3 gene have been associated with dysregulation of the immune system giving… read more here.
Keywords: abscessus infection; stat3; mycobacterium abscessus; patient ... See more keywords
Synthesis and Characterization of Phenylalanine Amides Active against Mycobacterium abscessus and Other Mycobacteria.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.3c00009
Abstract: Nα-2-thiophenoyl-d-phenylalanine-2-morpholinoanilide [MMV688845, Pathogen Box; Medicines for Malaria Venture; IUPAC: (2R)-N-(1-((2-morpholinophenyl)amino)-1-oxo-3-phenylpropan-2-yl)thiophene-2-carboxamide)] is a hit compound, which shows activity against Mycobacterium abscessus (MIC90 6.25-12.5 μM) and other mycobacteria. This work describes derivatization of MMV688845 by introducing a… read more here.
Keywords: phenylalanine; mycobacterium abscessus; synthesis; mycobacterium ... See more keywords
Development of Inhibitors of SAICAR Synthetase (PurC) from Mycobacterium abscessus Using a Fragment-Based Approach.
Sign Up to like & getrecommendations! Published in 2022 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.1c00432
Abstract: Mycobacterium abscessus (Mab) has emerged as a challenging threat to individuals with cystic fibrosis. Infections caused by this pathogen are often impossible to treat due to the intrinsic antibiotic resistance leading to lung malfunction and… read more here.
Keywords: mycobacterium abscessus; fragment based; saicar synthetase; synthetase purc ... See more keywords