Probing the structure-function relationship of Mycobacterium leprae HSP18 under different UV radiations.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.07.151
Abstract: Ultraviolet radiation, an effective sterilizing source, rapidly kills the causative organism (Mycobacterium leprae) of leprosy. But, the reasons behind this quick death are not clearly understood. Also, the impact of UV radiation on the antigen(s)… read more here.
Keywords: leprae; mycobacterium leprae; structure; function ... See more keywords
LEPStr: A database for Mycobacterium leprae short tandem repeats
Sign Up to like & getrecommendations! Published in 2020 at "Informatics in Medicine Unlocked"
DOI: 10.1016/j.imu.2020.100322
Abstract: Abstract Short tandem repeats are short arrays of nucleotide sequences, and they have vital roles in many biological processes, including modulation of transcription, enhancement of gene expression, adaptation to a particular environment, and link to… read more here.
Keywords: short tandem; repeat; database; mycobacterium leprae ... See more keywords
Ancient Mycobacterium leprae genomes from the mediaeval sites of Chichester and Raunds in England
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Archaeological Science"
DOI: 10.1016/j.jas.2019.105035
Abstract: Abstract We examined six skeletons from mediaeval contexts from two sites in England for the presence of Mycobacterium leprae DNA, each of the skeletons displaying osteological indicators of leprosy. Polymerase chain reactions directed at the… read more here.
Keywords: genomes mediaeval; leprae genomes; mycobacterium leprae; ancient mycobacterium ... See more keywords
Nasal PCR assay for the detection of Mycobacterium leprae pra gene to study subclinical infection in a community.
Sign Up to like & getrecommendations! Published in 2017 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2017.01.046
Abstract: Leprosy is a chronic infectious disease caused by Mycobacterium leprae. Identification of Mycobacterium leprae is difficult in part due to the inability of the leprosy bacillus to grow in vitro. A number of diagnostic methods for… read more here.
Keywords: nasal pcr; leprae; mycobacterium leprae; pra gene ... See more keywords
Unlocking Opportunities for Mycobacterium leprae and Mycobacterium ulcerans
Sign Up to like & getrecommendations! Published in 2024 at "ACS Infectious Diseases"
DOI: 10.1021/acsinfecdis.3c00371
Abstract: In the recent decade, scientific communities have toiled to tackle the emerging burden of drug-resistant tuberculosis (DR-TB) and rapidly growing opportunistic nontuberculous mycobacteria (NTM). Among these, two neglected mycobacteria species of the Acinetobacter family, Mycobacterium… read more here.
Keywords: mycobacterium leprae; leprae mycobacterium; drug; mycobacterium ulcerans ... See more keywords
Pathogenicity and virulence of Mycobacterium leprae
Sign Up to like & getrecommendations! Published in 2022 at "Virulence"
DOI: 10.1080/21505594.2022.2141987
Abstract: ABSTRACT Leprosy is caused by Mycobacterium leprae (M. leprae) and M. lepromatosis, an obligate intracellular organism, and over 200,000 new cases occur every year. M. leprae parasitizes histiocytes (skin macrophages) and Schwann cells in the… read more here.
Keywords: virulence mycobacterium; mycobacterium leprae; leprae; pathogenicity virulence ... See more keywords
Genetic variability, genotyping, and genomics of Mycobacterium leprae
Sign Up to like & getrecommendations! Published in 2025 at "FEMS Microbiology Reviews"
DOI: 10.1093/femsre/fuaf012
Abstract: Abstract Leprosy, caused by Mycobacterium leprae and Mycobacterium lepromatosis, remains a significant global health issue despite a tremendous decline in its worldwide prevalence in the last four decades. Mycobacterium leprae strains possess very limited genetic… read more here.
Keywords: genetic variability; mycobacterium leprae; leprae; mycobacterium ... See more keywords
Myelination key factor krox‐20 is downregulated in Schwann cells and murine sciatic nerves infected by Mycobacterium leprae
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Experimental Pathology"
DOI: 10.1111/iep.12309
Abstract: Schwann cells (SCs) critically maintain the plasticity of the peripheral nervous system. Peripheral nerve injuries and infections stimulate SCs in order to retrieve homeostasis in neural tissues. Previous studies indicate that Mycobacterium leprae (ML) regulates… read more here.
Keywords: krox; schwann cells; nerves infected; mycobacterium leprae ... See more keywords
Molecular and spatial evaluation of small rodents and Didelphimorphis infected with Mycobacterium leprae in the southern Amazon, Brazil
Sign Up to like & getrecommendations! Published in 2024 at "Zoonoses and Public Health"
DOI: 10.1111/zph.13160
Abstract: The high levels of recent transmission of leprosy worldwide demonstrate the necessity of epidemiologic surveillance to understand and control its dissemination. Brazil remains the second in number of cases around the world, indicating active transmission… read more here.
Keywords: spatial evaluation; molecular spatial; brazil; mycobacterium leprae ... See more keywords
Cell Biology of Intracellular Adaptation of Mycobacterium leprae in the Peripheral Nervous System.
Sign Up to like & getrecommendations! Published in 2019 at "Microbiology spectrum"
DOI: 10.1128/microbiolspec.bai-0020-2019
Abstract: The mammalian nervous system is invaded by a number of intracellular bacterial pathogens which can establish and progress infection in susceptible individuals. Subsequent clinical manifestation is apparent with the impairment of the functional units of… read more here.
Keywords: system; biology; mycobacterium leprae; nervous system ... See more keywords
Social and environmental conditions related to Mycobacterium leprae infection in children and adolescents from three leprosy endemic regions of Colombia
Sign Up to like & getrecommendations! Published in 2019 at "BMC Infectious Diseases"
DOI: 10.1186/s12879-019-4120-2
Abstract: BackgroundLeprosy is is still considered a public health issue and in Colombia 7–10% of new cases are found in children, indicating both active transmission and social inequality. We hypothesized that circulating antibodies against Natural Octyl… read more here.
Keywords: social environmental; leprae; mycobacterium leprae; children adolescents ... See more keywords