Probing the structure-function relationship of Mycobacterium leprae HSP18 under different UV radiations.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.07.151
Abstract: Ultraviolet radiation, an effective sterilizing source, rapidly kills the causative organism (Mycobacterium leprae) of leprosy. But, the reasons behind this quick death are not clearly understood. Also, the impact of UV radiation on the antigen(s)… read more here.
Keywords: leprae; mycobacterium leprae; structure; function ... See more keywords
LEPStr: A database for Mycobacterium leprae short tandem repeats
Sign Up to like & getrecommendations! Published in 2020 at "Informatics in Medicine Unlocked"
DOI: 10.1016/j.imu.2020.100322
Abstract: Abstract Short tandem repeats are short arrays of nucleotide sequences, and they have vital roles in many biological processes, including modulation of transcription, enhancement of gene expression, adaptation to a particular environment, and link to… read more here.
Keywords: short tandem; repeat; database; mycobacterium leprae ... See more keywords
Ancient Mycobacterium leprae genomes from the mediaeval sites of Chichester and Raunds in England
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Archaeological Science"
DOI: 10.1016/j.jas.2019.105035
Abstract: Abstract We examined six skeletons from mediaeval contexts from two sites in England for the presence of Mycobacterium leprae DNA, each of the skeletons displaying osteological indicators of leprosy. Polymerase chain reactions directed at the… read more here.
Keywords: genomes mediaeval; leprae genomes; mycobacterium leprae; ancient mycobacterium ... See more keywords
Nasal PCR assay for the detection of Mycobacterium leprae pra gene to study subclinical infection in a community.
Sign Up to like & getrecommendations! Published in 2017 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2017.01.046
Abstract: Leprosy is a chronic infectious disease caused by Mycobacterium leprae. Identification of Mycobacterium leprae is difficult in part due to the inability of the leprosy bacillus to grow in vitro. A number of diagnostic methods for… read more here.
Keywords: nasal pcr; leprae; mycobacterium leprae; pra gene ... See more keywords
Pathogenicity and virulence of Mycobacterium leprae
Sign Up to like & getrecommendations! Published in 2022 at "Virulence"
DOI: 10.1080/21505594.2022.2141987
Abstract: ABSTRACT Leprosy is caused by Mycobacterium leprae (M. leprae) and M. lepromatosis, an obligate intracellular organism, and over 200,000 new cases occur every year. M. leprae parasitizes histiocytes (skin macrophages) and Schwann cells in the… read more here.
Keywords: virulence mycobacterium; mycobacterium leprae; leprae; pathogenicity virulence ... See more keywords
Myelination key factor krox‐20 is downregulated in Schwann cells and murine sciatic nerves infected by Mycobacterium leprae
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Experimental Pathology"
DOI: 10.1111/iep.12309
Abstract: Schwann cells (SCs) critically maintain the plasticity of the peripheral nervous system. Peripheral nerve injuries and infections stimulate SCs in order to retrieve homeostasis in neural tissues. Previous studies indicate that Mycobacterium leprae (ML) regulates… read more here.
Keywords: krox; schwann cells; nerves infected; mycobacterium leprae ... See more keywords
Cell Biology of Intracellular Adaptation of Mycobacterium leprae in the Peripheral Nervous System.
Sign Up to like & getrecommendations! Published in 2019 at "Microbiology spectrum"
DOI: 10.1128/microbiolspec.bai-0020-2019
Abstract: The mammalian nervous system is invaded by a number of intracellular bacterial pathogens which can establish and progress infection in susceptible individuals. Subsequent clinical manifestation is apparent with the impairment of the functional units of… read more here.
Keywords: system; biology; mycobacterium leprae; nervous system ... See more keywords
Social and environmental conditions related to Mycobacterium leprae infection in children and adolescents from three leprosy endemic regions of Colombia
Sign Up to like & getrecommendations! Published in 2019 at "BMC Infectious Diseases"
DOI: 10.1186/s12879-019-4120-2
Abstract: BackgroundLeprosy is is still considered a public health issue and in Colombia 7–10% of new cases are found in children, indicating both active transmission and social inequality. We hypothesized that circulating antibodies against Natural Octyl… read more here.
Keywords: social environmental; leprae; mycobacterium leprae; children adolescents ... See more keywords
A phylogenomic study quantifies competing mechanisms for pseudogenization in prokaryotes—The Mycobacterium leprae case
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0204322
Abstract: Background Pseudogenes are non-functional sequences in the genome with homologous sequences that are functional (i.e. genes). They are abundant in eukaryotes where they have been extensively investigated, while in prokaryotes they are significantly scarcer and… read more here.
Keywords: pseudogenization; phylogenomic study; leprae; study quantifies ... See more keywords
Multiple strain infection of Mycobacterium leprae in a family having 4 patients: A study employing short tandem repeats
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0214051
Abstract: Background Leprosy is a slow, chronic disorder caused by Mycobacterium leprae. India has achieved elimination of leprosy in December 2005 but new cases are being detected and continue to occur in some endemic pockets. The… read more here.
Keywords: acquired infection; family patients; mycobacterium leprae; family ... See more keywords
Mycobacterium leprae promotes triacylglycerol de novo synthesis through induction of GPAT3 expression in human premonocytic THP-1 cells
Sign Up to like & getrecommendations! Published in 2021 at "PLoS ONE"
DOI: 10.1371/journal.pone.0249184
Abstract: Mycobacterium leprae (M. leprae) is the etiological agent of leprosy, and the skin lesions of lepromatous leprosy are filled with numerous foamy or xanthomatous histiocytes that are parasitized by M. leprae. Lipids are an important… read more here.
Keywords: leprae; expression; mycobacterium leprae; tag ... See more keywords