Mycobacterium tuberculosis TetR family transcriptional regulator Rv1019 is a negative regulator of the mfd‐mazG operon encoding DNA repair proteins
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Letters"
DOI: 10.1002/1873-3468.13861
Abstract: Rv1019, a member of an uncharacterized tetracycline resistance regulator family of transcriptional regulators of Mycobacterium tuberculosis H37Rv, was found to be differentially expressed during dormancy and reactivation in vitro. In this study, we show that… read more here.
Keywords: rv1019; family transcriptional; dna; mazg ... See more keywords
Delivery by Dendritic Mesoporous Silica Nanoparticles Enhances the Antimicrobial Activity of a Napsin-Derived Peptide Against Intracellular Mycobacterium tuberculosis.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202100453
Abstract: Tuberculosis remains a serious global health problem causing 1.3 million deaths annually. The causative pathogen Mycobacterium tuberculosis (Mtb) has developed several mechanisms to evade the immune system and resistances to many conventional antibiotics, so that… read more here.
Keywords: microscopy; mesoporous silica; activity; dendritic mesoporous ... See more keywords
2‐Aminoaryl‐3,5‐diaryl pyrazines: Synthesis, biological evaluation against Mycobacterium tuberculosis and docking studies
Sign Up to like & getrecommendations! Published in 2020 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.201900368
Abstract: Rationally designed Mycobacterium tuberculosis (Mtb) inhibitors were synthesized under Buchwald conditions using Pd2(dba)3/xantphos and the compounds were investigated for their biological activity against the Mtb standard strain H37Rv and two other clinically isolated multidrug‐resistant strains… read more here.
Keywords: docking studies; diaryl pyrazines; aminoaryl diaryl; mycobacterium tuberculosis ... See more keywords
Synthesis, in vitro antibacterial activity against Mycobacterium tuberculosis, and reverse docking‐based target fishing of 1,4‐benzoxazin‐2‐one derivatives
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DOI: 10.1002/ardp.202000199
Abstract: Seventeen 1,4‐benzoxazin‐2‐ones bearing the enaminone moiety and three of their analogs were tested for the antibacterial activity against Mycobacterium tuberculosis (H37Rv). Minimal bactericidal concentrations (MBCs) were determined after 41 days of incubation by BACTEC. 1,4‐Benzoxazin‐2‐ones… read more here.
Keywords: antibacterial activity; tuberculosis; activity mycobacterium; reverse docking ... See more keywords
Expression of ESAT‐6 antigen from Mycobacterium tuberculosis in broccoli: An edible plant
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.1867
Abstract: Tuberculosis (TB) is one of the major infectious diseases caused by Mycobacterium tuberculosis. The development of an effective and economical vaccine for controlling TB is essential especially for developing countries. Edible plants can serve as… read more here.
Keywords: tuberculosis; expression; antigen; vaccine ... See more keywords
Domain wise differentiation of Mycobacterium tuberculosis H37 Rv hypothetical proteins: A roadmap to discover bacterial survival potentials.
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology and applied biochemistry"
DOI: 10.1002/bab.2109
Abstract: Proteomic information revealed approximately 3923 proteins in Mycobacterium tuberculosis H37 Rv (M. tuberculosis) genome of which around ∼25% of proteins are hypothetical proteins (HPs). The present work comprises computational approaches to identify and characterize the… read more here.
Keywords: hypothetical proteins; tuberculosis; hps; tuberculosis h37 ... See more keywords
A Comprehensive Study of the Interaction between Peptidoglycan Fragments and the Extracellular Domain of Mycobacterium tuberculosis Ser/Thr Kinase PknB
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DOI: 10.1002/cbic.201700385
Abstract: The Mycobacterium tuberculosis Ser/Thr kinase PknB is implicated in the regulation of bacterial cell growth and cell division. The intracellular kinase function of PknB is thought to be triggered by peptidoglycan (PGN) fragments that are… read more here.
Keywords: kinase; spectroscopy; pknb; pgn ... See more keywords
A Simple Glycolipid Mimic of the Phosphatidylinositol Mannoside Core from Mycobacterium tuberculosis Inhibits Macrophage Cytokine Production
Sign Up to like & getrecommendations! Published in 2018 at "ChemBioChem"
DOI: 10.1002/cbic.201800150
Abstract: Glycolipids from Mycobacterium tuberculosis have a profound impact on the innate immune response of the host. Macrophage‐inducible C‐type lectin (Mincle) is a pattern‐recognition receptor that has been shown to bind trehalose dimycolate (TDM) from the… read more here.
Keywords: mannoside; mycobacterium; mycobacterium tuberculosis; cytokine production ... See more keywords
Natural products and their analogues acting against Mycobacterium tuberculosis: A recent update.
Sign Up to like & getrecommendations! Published in 2023 at "Drug development research"
DOI: 10.1002/ddr.22063
Abstract: Tuberculosis (TB) remains one of the deadliest infectious diseases caused by Mycobacterium tuberculosis (M.tb). It is responsible for significant causes of mortality and morbidity worldwide. M.tb possesses robust defense mechanisms against most antibiotic drugs and… read more here.
Keywords: mycobacterium tuberculosis; products analogues; tuberculosis; natural products ... See more keywords
The role of two‐component systems in the physiology of Mycobacterium tuberculosis
Sign Up to like & getrecommendations! Published in 2018 at "IUBMB Life"
DOI: 10.1002/iub.1872
Abstract: Tuberculosis is a global health problem, with a third of the world's population infected with the bacillus, Mycobacterium tuberculosis. The problem is exacerbated by the emergence of multidrug resistant and extensively drug resistant strains. The… read more here.
Keywords: physiology; tuberculosis; component systems; two component ... See more keywords
Targeting amino acid metabolism of Mycobacterium tuberculosis for developing inhibitors to curtail its survival
Sign Up to like & getrecommendations! Published in 2021 at "IUBMB Life"
DOI: 10.1002/iub.2455
Abstract: Tuberculosis caused by the bacterium, Mycobacterium tuberculosis (Mtb), continues to remain one of the most devastating infectious diseases afflicting humans. Although there are several drugs for treating tuberculosis available currently, the emergence of the drug… read more here.
Keywords: amino acid; developing inhibitors; survival; tuberculosis ... See more keywords