Mycobactin Analogues with Excellent Pharmacokinetic Profile Demonstrate Potent Antitubercular Specific Activity and Exceptional Efflux Pump Inhibition.
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DOI: 10.1021/acs.jmedchem.1c01349
Abstract: In this study, we have designed and synthesized pyrazoline analogues that partially mimic the structure of mycobactin, to address the requirement of novel therapeutics to tackle the emerging global challenge of antimicrobial resistance (AMR). Our… read more here.
Keywords: pump inhibition; pharmacokinetic profile; efflux pump; mycobactin ... See more keywords