Conditions for Handling and Optimal Storage of Mycolactone.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1779-3_12
Abstract: The successful isolation of mycolactone in a laboratory or from a clinical sample relies on proper handling and storage of the toxin. Mycolactone is a light-sensitive and an amphiphilic toxin produced by Mycobacterium ulcerans. The… read more here.
Keywords: biochemistry; storage mycolactone; storage; sample ... See more keywords
Mycolactone enhances the Ca2+ leak from endoplasmic reticulum by trapping Sec61 translocons in a Ca2+ permeable state
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DOI: 10.1042/bcj20210345
Abstract: The Mycobacterium ulcerans exotoxin, mycolactone, is an inhibitor of co-translational translocation via the Sec61 complex. Mycolactone has previously been shown to bind to, and alter the structure of the major translocon subunit Sec61α, and change… read more here.
Keywords: endoplasmic reticulum; mycolactone enhances; mycolactone; ca2 leak ... See more keywords
Aberrant stromal tissue factor localisation and mycolactone-driven vascular dysfunction, exacerbated by IL-1β, are linked to fibrin formation in Buruli ulcer lesions
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DOI: 10.1371/journal.ppat.1010280
Abstract: Buruli ulcer (BU) is a neglected tropical disease caused by subcutaneous infection with Mycobacterium ulcerans and its exotoxin mycolactone. BU displays coagulative necrosis and widespread fibrin deposition in affected skin tissues. Despite this, the role… read more here.
Keywords: vascular dysfunction; factor; buruli ulcer; mycolactone ... See more keywords
Density Functional Theory-Based Studies Predict Carbon Nanotubes as Effective Mycolactone Inhibitors
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DOI: 10.3390/molecules27144440
Abstract: Fullerenes, boron nitride nanotubes (BNNTs), and carbon nanotubes (CNTs) have all been extensively explored for biomedical purposes. This work describes the use of BNNTs and CNTs as mycolactone inhibitors. Density functional theory (DFT) has been… read more here.
Keywords: functional theory; mycolactone inhibitors; carbon nanotubes; mycolactone ... See more keywords
Molecular Docking and Dynamics Simulation Studies Predict Munc18b as a Target of Mycolactone: A Plausible Mechanism for Granule Exocytosis Impairment in Buruli Ulcer Pathogenesis
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DOI: 10.3390/toxins11030181
Abstract: Ulcers due to infections with Mycobacterium ulcerans are characterized by complete lack of wound healing processes, painless, an underlying bed of host dead cells and undermined edges due to necrosis. Mycolactone, a macrolide produced by… read more here.
Keywords: granule exocytosis; mycolactone; buruli ulcer; exocytosis ... See more keywords
Understanding the Significance of Biochemistry in the Storage, Handling, Purification, and Sampling of Amphiphilic Mycolactone
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DOI: 10.3390/toxins11040202
Abstract: Mycolactone, the amphiphilic macrolide toxin secreted by Mycobacterium ulcerans, plays a significant role in the pathology and manifestations of Buruli ulcer (BU). Consequently, it follows that the toxin is a suitable target for the development… read more here.
Keywords: biochemistry; mycolactone; toxin; storage handling ... See more keywords
From Bacterial Toxin to Therapeutic Agent: The Unexpected Fate of Mycolactone
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DOI: 10.3390/toxins15060369
Abstract: “Recognizing a surprising fact is the first step towards discovery.” This famous quote from Louis Pasteur is particularly appropriate to describe what led us to study mycolactone, a lipid toxin produced by the human pathogen… read more here.
Keywords: toxin therapeutic; toxin; therapeutic agent; mycolactone ... See more keywords
A Bacterial Toxin with Analgesic Properties: Hyperpolarization of DRG Neurons by Mycolactone
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DOI: 10.3390/toxins9070227
Abstract: Mycolactone, a polyketide molecule produced by Mycobacterium ulcerans, is the etiological agent of Buruli ulcer. This lipid toxin is endowed with pleiotropic effects, presents cytotoxic effects at high doses, and notably plays a pivotal role… read more here.
Keywords: mycolactone; bacterial toxin; drg neurons; toxin analgesic ... See more keywords