The One That Got Away: How Macrophage-Derived IL-1β Escapes the Mycolactone-Dependent Sec61 Blockade in Buruli Ulcer
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DOI: 10.3389/fimmu.2021.788146
Abstract: Buruli ulcer (BU), caused by Mycobacterium ulcerans, is a devastating necrotizing skin disease. Key to its pathogenesis is mycolactone, the exotoxin virulence factor that is both immunosuppressive and cytotoxic. The discovery that the essential Sec61… read more here.
Keywords: blockade; buruli ulcer; mycolactone dependent; sec61 ... See more keywords