Mycolactone enhances the Ca2+ leak from endoplasmic reticulum by trapping Sec61 translocons in a Ca2+ permeable state
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DOI: 10.1042/bcj20210345
Abstract: The Mycobacterium ulcerans exotoxin, mycolactone, is an inhibitor of co-translational translocation via the Sec61 complex. Mycolactone has previously been shown to bind to, and alter the structure of the major translocon subunit Sec61α, and change… read more here.
Keywords: endoplasmic reticulum; mycolactone enhances; mycolactone; ca2 leak ... See more keywords