Engineering the Mycomembrane of Live Mycobacteria with an Expanded Set of Trehalose Monomycolate Analogues
Sign Up to like & getrecommendations! Published in 2019 at "ChemBioChem"
DOI: 10.1002/cbic.201800687
Abstract: Mycobacteria and related organisms in the Corynebacterineae suborder are characterized by a distinctive outer membrane referred to as the mycomembrane. Biosynthesis of the mycomembrane occurs through an essential process called mycoloylation, which involves antigen 85… read more here.
Keywords: trehalose monomycolate; cell; cell labeling; tmm ... See more keywords
A FRET-Based Fluorogenic Trehalose Dimycolate Analogue for Probing Mycomembrane-Remodeling Enzymes of Mycobacteria
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DOI: 10.1021/acsomega.9b00130
Abstract: The mycobacterial outer membrane, or mycomembrane, is essential for the viability and virulence of Mycobacterium tuberculosis and related pathogens. The mycomembrane is a dynamic structure, whose chemical composition and biophysical properties can change during stress… read more here.
Keywords: mycomembrane remodeling; tdm; mycomembrane; activity ... See more keywords
PGRS domain structures: Doomed to sail the mycomembrane
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DOI: 10.1371/journal.ppat.1010760
Abstract: The impact of artificial intelligence (AI) in understanding biological processes is potentially immense. Structural elucidation of mycobacterial PE_PGRS is sustenance to unveil the role of these enigmatic proteins. We propose a PGRS “sailing” model as… read more here.
Keywords: pgrs domain; doomed sail; mycomembrane; domain structures ... See more keywords