Enhanced Production of Mycophenolic Acid from Penicillium brevicompactum via Optimized Fermentation Strategy
Sign Up to like & getrecommendations! Published in 2022 at "Applied Biochemistry and Biotechnology"
DOI: 10.1007/s12010-022-03886-9
Abstract: Mycophenolic acid (MPA) is an occurring antibiotic produced through Penicillium brevicompactum. Its production was achieved by systematic process optimization under submerged fermentation. In shake flask, single-factor test experiments, Box–Behnken design (BBD) experiments, and fermentation strategy… read more here.
Keywords: mycophenolic acid; fermentation; penicillium brevicompactum; production ... See more keywords
Agro-industrial byproducts for production of the immunosuppressant mycophenolic acid by Penicillium roqueforti under solid-state fermentation: Enhanced production by ultraviolet and gamma irradiation
Sign Up to like & getrecommendations! Published in 2019 at "Biocatalysis and Agricultural Biotechnology"
DOI: 10.1016/j.bcab.2019.01.053
Abstract: Abstract Different agro-industrial materials were screened for their performance on production of mycophenolic acid (MPA) by two strains of Penicillium roqueforti (AG101 and LG109) under solid-state fermentation (SSF). Sugarcane bagasse followed by corn stalks and… read more here.
Keywords: penicillium roqueforti; agro industrial; production; mycophenolic acid ... See more keywords
Synthesis and antimicrobial activity of amino acid and peptide derivatives of mycophenolic acid
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Medicinal Chemistry"
DOI: 10.1016/j.ejmech.2017.11.094
Abstract: Abstract The series of 16 novel amino acid and peptide mycophenolic acid (MPA) derivatives was obtained as potential antibacterial agents. Coupling of MPA with respective amines was optimized with condensing reagents such as EDCI/DMAP and… read more here.
Keywords: amino; amino acid; acid peptide; mycophenolic acid ... See more keywords
Immunosuppressive properties of amino acid and peptide derivatives of mycophenolic acid.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.112091
Abstract: Mycophenolic acid (MPA) was coupled with amino acids and biologically active peptides including derivatives of tuftsin to modify its immunosuppressive properties. Both amino acid unit in the case of simple MPA amides and modifications within… read more here.
Keywords: immunosuppressive properties; amino acid; acid peptide; mycophenolic acid ... See more keywords
Molecular screening of xerophilic Aspergillus strains producing mycophenolic acid.
Sign Up to like & getrecommendations! Published in 2017 at "Fungal biology"
DOI: 10.1016/j.funbio.2016.10.001
Abstract: Mycophenolic acid (MPA) is the fungal secondary metabolite displaying several biological properties. Up to now, screening of fungal strains producing MPA has mainly been the result of the search of this molecule in their culture… read more here.
Keywords: expression level; strains producing; mycophenolic acid; expression ... See more keywords
Structural Basis of the Change in the Interaction Between Mycophenolic Acid and Subdomain IIA of Human Serum Albumin During Renal Failure.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01790
Abstract: Mycophenolic acid (MP) is an active metabolite of mycophenolate mofetil, a widely used immunosuppressive drug. MP normally exhibits high plasma protein binding (97-99%), but its binding rate is decreased in patients with renal insufficiency. This… read more here.
Keywords: renal failure; subdomain iia; protein binding; mycophenolic acid ... See more keywords
The Immunosuppressant Mycophenolic Acid Alters Nucleotide and Lipid Metabolism in an Intestinal Cell Model
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep45088
Abstract: The study objective was to elucidate the molecular mechanisms underlying the negative effects of mycophenolic acid (MPA) on human intestinal cells. Effects of MPA exposure and guanosine supplementation on nucleotide concentrations in LS180 cells were… read more here.
Keywords: mycophenolic acid; immunosuppressant mycophenolic; lipid metabolism; mpa ... See more keywords
MRP4 is responsible for the efflux transport of mycophenolic acid β-d glucuronide (MPAG) from hepatocytes to blood
Sign Up to like & getrecommendations! Published in 2020 at "Xenobiotica"
DOI: 10.1080/00498254.2020.1813352
Abstract: Abstract Mycophenolic acid (MPA) has become a cornerstone of immunosuppressive therapy, in particular for transplant patients. In the gastrointestinal tract, the liver and the kidney, MPA is mainly metabolized into phenyl-β-d glucuronide (MPAG). Knowledge about… read more here.
Keywords: glucuronide mpag; mpag; transport; mycophenolic acid ... See more keywords
86 Fungi and Mycotoxins Occupational Exposure – Unveiling the Contamination in Different Settings from Portugal
Sign Up to like & getrecommendations! Published in 2023 at "Annals of Work Exposures and Health"
DOI: 10.1093/annweh/wxac087.025
Abstract: This study intends to present an overview from the assessments of fungal contamination and mycotoxins performed in three different occupational environments (Firefighters headquarters - FFH; Waste collection trucks – WCT and; Cemeteries - CM). Active… read more here.
Keywords: fungi mycotoxins; settled dust; contamination; mycophenolic acid ... See more keywords
Comparison of a Point-of-Care Testing with EMIT and LC-MS/MS Methods for Therapeutic Drug Monitoring of Mycophenolic Acid: A Preliminary Study.
Sign Up to like & getrecommendations! Published in 2020 at "Therapeutic Drug Monitoring"
DOI: 10.1097/ftd.0000000000000861
Abstract: BACKGROUND For mycophenolic acid (MPA), therapeutic drug monitoring (TDM) is an essential tool for dosage optimization in transplant recipients and autoimmune diseases. In China, a new commercial kit using an immunochromatographic assay (FICA) with a… read more here.
Keywords: mycophenolic acid; fica; therapeutic drug; drug monitoring ... See more keywords
Estimation of Mycophenolic Acid Exposure in Chinese Renal Transplant Patients by a Joint Deep Learning Model
Sign Up to like & getrecommendations! Published in 2022 at "Therapeutic Drug Monitoring"
DOI: 10.1097/ftd.0000000000001020
Abstract: Supplemental Digital Content is Available in the Text. Background: To predict mycophenolic acid (MPA) exposure in renal transplant recipients using a deep learning model based on a convolutional neural network with bilateral long short-term memory… read more here.
Keywords: chinese renal; transplant patients; mycophenolic acid; model ... See more keywords