Schisandrin B Attenuates Diabetic Cardiomyopathy by Targeting MyD88 and Inhibiting MyD88‐Dependent Inflammation
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202202590
Abstract: Diabetes manifests as chronic inflammation and leads to the development diabetic cardiomyopathy (DCM). Targeting key proteins in inflammatory signaling may provide new therapy for DCM. In this study, the authors explore the pharmacological effects and… read more here.
Keywords: inflammation; myd88; myd88 dependent; diabetic cardiomyopathy ... See more keywords
Deletion of MyD88 in astrocytes prevents β‐amyloid‐induced neuropathology in mice
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24285
Abstract: As the understanding of immune responses in Alzheimer's disease (AD) is in its early phases, there remains an urgency to identify the cellular and molecular processes driving chronic inflammation. In AD, a subpopulation of astrocytes… read more here.
Keywords: astrocytes prevents; deletion myd88; myd88 astrocytes; myd88 ... See more keywords
Inhibition of boldenone-induced aggression in rats by curcumin: Targeting TLR4/MyD88/TRAF-6/NF-κB pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.22936
Abstract: The illicit abuse of anabolic steroids is associated with brutal aggression, which represents a serious health hazard and social threat. Boldenone is commonly used for doping by athletes and adolescents for esthetic purposes and to… read more here.
Keywords: traf; boldenone; aggression rats; aggression ... See more keywords
Loss of BMI‐1 dampens migration and EMT of colorectal cancer in inflammatory microenvironment through TLR4/MD‐2/MyD88‐mediated NF‐κB signaling
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26353
Abstract: Increasing evidence from various clinical and experimental studies has demonstrated that the inflammatory microenvironment created by immune cells facilitates tumor migration. Epithelial‐mesenchymal transition (EMT) is involved in the progression of cancer invasion and metastasis in… read more here.
Keywords: bmi; inflammatory microenvironment; migration; cancer ... See more keywords
The miRNA‐149‐5p/MyD88 axis is responsible for ursolic acid‐mediated attenuation of the stemness and chemoresistance of non‐small cell lung cancer cells
Sign Up to like & getrecommendations! Published in 2019 at "Environmental Toxicology"
DOI: 10.1002/tox.22891
Abstract: Although the inhibitory roles of ursolic acid (UA) have been established in various tumors, its effects on the stemness of non‐small cell lung cancer (NSCLC) cells are still unclear. Here, we constructed NSCLC cells with… read more here.
Keywords: 149 myd88; stemness; a549 cells; myd88 axis ... See more keywords
Silencing TLR4/MyD88/NF-κB Signaling Pathway Alleviated Inflammation of Corneal Epithelial Cells Infected by ISE
Sign Up to like & getrecommendations! Published in 2020 at "Inflammation"
DOI: 10.1007/s10753-020-01363-1
Abstract: The regulatory role of toll-like receptor 4 (TLR4) in the inactivate staphylococcus epidermidis (ISE)-induced cornea inflammation is not well investigated. Here, TLR4 silence could decrease inflammatory cytokines in corneal epithelial cells treated with ISE. The… read more here.
Keywords: epithelial cells; ise; corneal epithelial; inflammation ... See more keywords
Abnormal brain structure and behavior in MyD88-deficient mice
Sign Up to like & getrecommendations! Published in 2021 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2020.09.024
Abstract: While the original protein Toll in Drosophila melanogaster regulates both host defense and morphogenesis, the role of its ortholog Toll-like receptors (TLRs), the interleukin 1 receptor (IL-1R) family, and the associated signaling pathways in mammalian… read more here.
Keywords: behavior; mice; brain; myd88 ... See more keywords
Dectin-1 Activation Exacerbates Obesity and Insulin Resistance in the Absence of MyD88.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.05.059
Abstract: The underlying mechanism by which MyD88 regulates the development of obesity, metainflammation, and insulin resistance (IR) remains unknown. Global deletion of MyD88 in high-fat diet (HFD)-fed mice resulted in increased weight gain, impaired glucose homeostasis,… read more here.
Keywords: cd11c macrophages; insulin resistance; dectin; absence myd88 ... See more keywords
The inhibition of microRNA-203 on ischemic reperfusion injury after total knee arthroplasty via suppressing MYD88-mdiated toll-like receptor signaling pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Gene"
DOI: 10.1016/j.gene.2019.02.030
Abstract: Ischemia reperfusion injury (IRI), a complex phenomenon often encountered in surgery, can lead to local and distant tissue destruction and sometimes even death. microRNA-203 (miR-203) has been reported to negatively regulate ischemia induced microglia activation… read more here.
Keywords: signaling pathway; mir 203; iri; expression ... See more keywords
Cloning, characterization, and function of MyD88 in silvery pomfret (Pampus argenteus) in response to bacterial challenge.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2017.05.039
Abstract: Myeloid differentiation factor 88 (MyD88) is a key and universal downstream adapter for most Toll-like receptors (TLRs) and plays an important role in both the innate and adaptive immune response. In this study, the full-length… read more here.
Keywords: response; pamyd88; pampus argenteus; silvery pomfret ... See more keywords
A homogalacturonan from Hippophae rhamnoides L. Berries enhance immunomodulatory activity through TLR4/MyD88 pathway mediated activation of macrophages.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2017.09.083
Abstract: Our previous study isolated a natural high-methoxyl homogalacturonan (HRWP-A) from Hippophae rhamnoides and showed antitumor activity in vivo. In this study, the immunomodulatory activity and mechanisms of action of HRWP-A were further investigated. Results showed… read more here.
Keywords: hippophae rhamnoides; activation; tlr4; activity ... See more keywords