Quantitative analysis of MYD88 L265P mutations by digital PCR is an independent prognostic factor for CNS relapse as well as systemic relapse and poor outcome
Sign Up to like & getrecommendations! Published in 2017 at "Hematological Oncology"
DOI: 10.1002/hon.2439
Abstract: 290 QUANTITATIVE ANALYSIS OF MYD88 L265P MUTATIONS BY DIGITAL PCR IS AN INDEPENDENT PROGNOSTIC FACTOR FOR CNS RELAPSE AS WELL AS SYSTEMIC RELAPSE AND POOR OUTCOME N. Nishimura* | R. Asaka | K. Takeuchi |… read more here.
Keywords: quantitative analysis; pathology; relapse; myd88 l265p ... See more keywords
Frequency of MYD88 L256P mutation and its correlation with clinico-hematological profile in mature B-cell neoplasm.
Sign Up to like & getrecommendations! Published in 2020 at "Hematology/oncology and stem cell therapy"
DOI: 10.1016/j.hemonc.2020.10.003
Abstract: OBJECTIVE/BACKGROUND B-cell neoplasms are clonal tumors of B cells at various stages of maturation, including diffuse large B-cell lymphoma (DLBCL), chronic lymphocytic lymphoma (CLL), Burkitt lymphoma (BL), lymphoplasmacytic lymphoma (LPL)/Waldenström's macroglobulinemia (WM), splenic marginal zone… read more here.
Keywords: lymphoma; l265p mutation; myd88 l265p; cell ... See more keywords
Serial Detection of MYD88 L265P Mutation in the Aqueous Humor of a Patient with Vitreoretinal Lymphoma for Disease Monitoring
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DOI: 10.1080/09273948.2020.1802488
Abstract: ABSTRACT Purpose To report a case of a patient whose MYD88 mutation disappeared from the aqueous humor following treatment with intravitreal methotrexate. Methods A retrospective review of clinical, histopathological and imaging records. Results A 49-year-old… read more here.
Keywords: myd88 l265p; l265p mutation; mutation; vitreoretinal lymphoma ... See more keywords
To select or not to select? The role of B‐cell selection in determining the MYD88 mutation status in Waldenström Macroglobulinaemia
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DOI: 10.1111/bjh.13996
Abstract: Waldenstr€ om Macroglobulinaemia (WM) is a B-cell malignancy characterized by bone marrow (BM) infiltration with lymphoplasmacytic lymphoma and production of a monoclonal immunoglobulin (Ig) M protein (Owen et al, 2003). The tumour cell population in… read more here.
Keywords: myd88 l265p; cell; myd88; waldenstr macroglobulinaemia ... See more keywords
Cadherin‐11 (CDH11) expression in the peripheral blood of patients with active Multiple Myeloma
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DOI: 10.1111/bjh.14105
Abstract: recurrent mutations in chronic lymphocytic leukaemia. Nature, 475, 101–105. Treon, S.P., Xu, L., Yang, G., Zhou, Y., Liu, X., Cao, Y., Sheehy, P., Manning, R.J., Patterson, C.J., Tripsas, C., Arcaini, L., Pinkus, G.S., Rodig, S.J.,… read more here.
Keywords: waldenstrom macroglobulinemia; treon; myd88 l265p; yang zhou ... See more keywords
Bioimpedance vector analysis for the detection of extracellular volume overload and sarcopenia in systemic AL amyloidosis
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DOI: 10.1111/bjh.15675
Abstract: Additional supporting information may be found online in the Supporting Information section at the end of the article. Table SI. MYD88 p.(L265P) analysis on retrospectively collected CSF samples of PCNSL patients compared to routine biomarkers.… read more here.
Keywords: l265p analysis; pcnsl patients; analysis; myd88 l265p ... See more keywords
Combining MYD88 L265P mutation detection and clonality determination on CSF cellular and cell-free DNA improves diagnosis of primary CNS lymphoma.
Sign Up to like & getrecommendations! Published in 2023 at "British journal of haematology"
DOI: 10.1111/bjh.18758
Abstract: Diagnosis of primary central nervous system lymphoma (PCNSL) is challenging, and although brain biopsy remains the gold standard, cerebrospinal fluid (CSF) constitutes a less invasive source of lymphomatous biomarkers. In a retrospective cohort of 54… read more here.
Keywords: cell; csf; myd88 l265p; diagnosis primary ... See more keywords
Evaluation of MYD88 p.L265P detection by digital droplet polymerase chain reaction in cerebrospinal fluid for integrated diagnosis of primary large B‐cell lymphoma of the central nervous system
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DOI: 10.1111/bjh.20167
Abstract: Combining MYD88 analysis with complementary diagnostic markers improves detection rates and provides a more comprehensive diagnostic approach. Further studies are needed to refine these criteria and integrate them into clinical practice read more here.
Keywords: detection; detection digital; evaluation myd88; myd88 l265p ... See more keywords
Rapid detection of the MYD88 L265P mutation for pre‐ and intra‐operative diagnosis of primary central nervous system lymphoma
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DOI: 10.1111/cas.15762
Abstract: The myeloid differentiation primary response gene 88 (MYD88) L265P mutation is a disease‐specific mutation of primary central nervous system lymphoma (PCNSL) among the central nervous system tumors. Accordingly, this mutation is considered a reliable diagnostic… read more here.
Keywords: detection myd88; myd88 l265p; myd88; l265p mutation ... See more keywords
Guiding Treatment and Clinical Management of Patients with CNS Lymphomas By Minimal-Invasive Detection of Circulating Tumor DNA in Cerebrospinal Fluid
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DOI: 10.1182/blood-2024-202943
Abstract: Introduction: Central nervous system lymphomas (CNSL) are aggressive extranodal Non-Hodgkin lymphomas confined to the CNS compartment, mostly classified as diffuse large B-cell lymphomas. The gold standard for CNSL diagnosis is histopathological assessment of tumor tissue… read more here.
Keywords: brain; minimal invasive; cnsl; csf ... See more keywords
The use of MYD88 and IGH PCR in the diagnosis and follow up of Βing-neel syndrome
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DOI: 10.1182/blood-2025-5736
Abstract: Background: Bing-Neel syndrome (BNS) is a rare central nervous system involvement of lymphoplasmacytic lymphoma (LPL). The diagnosis is made using a combination of cerebrospinal fluid (CSF) cytology, flow cytometry, detection of the MYD88 L265 mutation,… read more here.
Keywords: igh pcr; pcr; l265p igh; cytology ... See more keywords