Abstract LB-083: Targeting IRAK4 disrupts inflammatory pathways and tumor microenvironment in chronic lymphocytic leukemia regardless MYD88 mutational status
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DOI: 10.1158/1538-7445.am2018-lb-083
Abstract: BACKGROUND & AIM. Interleukin-1 receptor-associated kinase 4 (IRAK4) plays a critical role in Toll-like receptor (TLR) signal transduction and the innate immune response. Recruitment of IRAK4 to these receptors and its subsequent activation is facilitated… read more here.
Keywords: cll; mutational status; myd88 mutational; chronic lymphocytic ... See more keywords