Paeonol Alleviates Subarachnoid Hemorrhage Injury in Rats Through Upregulation of SIRT1 and Inhibition of HMGB1/TLR4/MyD88/NF‐κB Pathway
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.70035
Abstract: Paeonol is a principle bioactive compound separated from the root bark of Cortex Moutan and has been shown to confer various biological functions, including antineuroinflammation and neuroprotection. Inflammation, blood–brain barrier (BBB), permeability, and apoptosis are… read more here.
Keywords: brain; inhibition; myd88 pathway; sirt1 inhibition ... See more keywords
MicroRNA‐421 suppresses the apoptosis and autophagy of hippocampal neurons in epilepsy mice model by inhibition of the TLR/MYD88 pathway
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26498
Abstract: Epilepsy is a group of neurological disorders characterized by epileptic seizures. In this study, we aim to explore the role of microRNA‐421 (miR‐421) in hippocampal neurons of epilepsy mice via the TLR/MYD88 pathway. Forty mice… read more here.
Keywords: hippocampal neurons; tlr myd88; neurons epilepsy; model ... See more keywords
Eupatilin attenuates the inflammatory response induced by intracerebral hemorrhage through the TLR4/MyD88 pathway.
Sign Up to like & getrecommendations! Published in 2019 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2019.105837
Abstract: BACKGROUND Intracranial hemorrhage (ICH) is one of the most common brain traumas, and inflammation caused by ICH seriously affects the quality of life and prognosis of patients. Eupatilin has been shown to have anti-inflammatory effects… read more here.
Keywords: tlr4 myd88; inflammatory response; hemorrhage; myd88 pathway ... See more keywords
Lactoferrin suppresses LPS-induced expression of HMGB1, microRNA 155, 146, and TLR4/MyD88/NF-кB pathway in RAW264.7 cells
Sign Up to like & getrecommendations! Published in 2021 at "Immunopharmacology and Immunotoxicology"
DOI: 10.1080/08923973.2021.1872616
Abstract: Abstract Objective This current study evaluated the underlying mechanisms of LF against the inflammatory microRNAs (miRNAs), HMGB1 expression, and TLR4-MyD88-NF-кB pathway in LPS-activated murine RAW264.7 cells. Methods MTT assay was used to assess cell metabolism… read more here.
Keywords: myd88 pathway; expression; tlr4 myd88;
Protective Effects of the Wenfei Buqi Tongluo Formula on the Inflammation in Idiopathic Pulmonary Fibrosis through Inhibiting the TLR4/MyD88/NF-κB Pathway
Sign Up to like & getrecommendations! Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/8752325
Abstract: Background Idiopathic pulmonary fibrosis (IPF) is a progressive disease with high mortality and poor prognosis. The prognostic signatures related to conventional therapy response remain limited. The Wenfei Buqi Tongluo (WBT) formula, a traditional Chinese medicine… read more here.
Keywords: inflammation; wbt formula; pharmacology; formula ... See more keywords
RIPK3 regulates microglial polarization through the TLR4/MyD88 pathway in neuropathic pain
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Pain"
DOI: 10.1177/17448069251377861
Abstract: Peripheral nerve injury activates microglia in the spinal, promoting microglial polarization and facilitating neuropathic pain progression. Necroptosis, a form of cell death, plays a crucial role in various neurological diseases and receptor-interacting protein kinases 3(RIPK3)… read more here.
Keywords: myd88 pathway; microglial polarization; neuropathic pain; polarization ... See more keywords
Anethole ameliorates inflammation induced by monosodium urate in an acute gouty arthritis model via inhibiting TLRs/MyD88 pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Allergologia et immunopathologia"
DOI: 10.15586/aei.v50i6.682
Abstract: OBJECTIVE To assess the effects of anethole on monosodium urate (MSU)-induced inflammatory response, investigate its role in acute gouty arthritis (AGA), and verify its molecular mechanism. METHODS Hematoxylin and eosin staining assay and time-dependent detection… read more here.
Keywords: induced aga; aga mice; myd88 pathway; msu induced ... See more keywords
Transcutaneous electrical acupoint stimulation alleviates cerebral ischemic injury through the TLR4/MyD88/NF-κ B pathway
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2023.1343842
Abstract: This study was to explore whether transcutaneous electrical acupoint stimulation (TEAS) treatment could mediate inflammation, apoptosis, and pyroptosis of neuronal cells and microglia activation through the TLR4/MyD88/NF-κB pathway in the early stage of ischemic stroke.… read more here.
Keywords: acupoint stimulation; transcutaneous electrical; myd88 pathway; electrical acupoint ... See more keywords