Age‐related changes in myelin of axons of the corpus callosum and cognitive decline in common marmosets
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Primatology"
DOI: 10.1002/ajp.22949
Abstract: Executive control is a higher‐level cognitive function that involves a range of different processes that are involved in the planning, coordination, execution, and inhibition of responses. Many of the processes associated with executive control, such… read more here.
Keywords: common marmosets; corpus callosum; age; myelin ... See more keywords
Axon‐Myelin Unit Blistering as Early Event in MS Normal Appearing White Matter
Sign Up to like & getrecommendations! Published in 2021 at "Annals of Neurology"
DOI: 10.1002/ana.26014
Abstract: Multiple sclerosis (MS) is a chronic neuroinflammatory and neurodegenerative disease of unknown etiology. Although the prevalent view regards a CD4+‐lymphocyte autoimmune reaction against myelin at the root of the disease, recent studies propose autoimmunity as… read more here.
Keywords: axon myelin; blistering early; unit blistering; event ... See more keywords
Fractional anisotropy from diffusion tensor imaging correlates with acute astrocyte and myelin swelling in neonatal swine models of excitotoxic and hypoxic‐ischemic brain injury
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.25121
Abstract: The specific cytopathology that causes abnormal fractional anisotropy (FA) and mean diffusivity (MD) from diffusion tensor imaging (DTI) after neonatal hypoxia‐ischemia (HI) is not completely understood. The panoply of cell types in the brain might… read more here.
Keywords: tensor imaging; fractional anisotropy; brain; injury ... See more keywords
Widespread transcriptional alternations in oligodendrocytes in the adult mouse brain following chronic stress
Sign Up to like & getrecommendations! Published in 2018 at "Developmental Neurobiology"
DOI: 10.1002/dneu.22533
Abstract: Emerging evidence shows that oligodendrogenesis and myelination are highly responsive to behavioral experience, including physical activity and social experience. This form of myelin plasticity is being increasingly appreciated and examined in the prefrontal cortex (PFC),… read more here.
Keywords: adult; widespread transcriptional; transcriptional alternations; stress ... See more keywords
White matter tauopathy: Transient functional loss and novel myelin remodeling
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DOI: 10.1002/glia.23286
Abstract: Early white matter (WM) changes are common in dementia and may contribute to functional decline. We here examine this phenomenon in an induced dementia model for the first time. We report a novel and selective… read more here.
Keywords: dementia; myelin remodeling; pathology; myelin ... See more keywords
Ermin is a p116RIP‐interacting protein promoting oligodendroglial differentiation and myelin maintenance
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DOI: 10.1002/glia.23838
Abstract: Myelin sheaths, which insulate the axons and ensure saltatory conduction of the nerve impulse, are generated and maintained via largely uncharacterized mechanisms. Ermin is an oligodendrocyte‐specific protein associated with the cytoskeleton, but how it regulates… read more here.
Keywords: oligodendroglial differentiation; differentiation; myelin maintenance; interacting protein ... See more keywords
The orphan G protein‐coupled receptor GPR149 is a negative regulator of myelination and remyelination
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DOI: 10.1002/glia.24233
Abstract: Myelin sheath, formed by oligodendrocytes (OLs) in the central nervous system (CNS) and Schwann cells in periphery, plays a critical role in supporting neuronal functions. OLs, differentiated from oligodendrocyte precursor cells (OPCs), are important for… read more here.
Keywords: orphan protein; remyelination; gpr149; myelination ... See more keywords
Focused ion beam‐scanning electron microscopy links pathological myelin outfoldings to axonal changes in mice lacking Plp1 or Mag
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DOI: 10.1002/glia.24290
Abstract: Healthy myelin sheaths consist of multiple compacted membrane layers closely encasing the underlying axon. The ultrastructure of CNS myelin requires specialized structural myelin proteins, including the transmembrane‐tetraspan proteolipid protein (PLP) and the Ig‐CAM myelin‐associated glycoprotein… read more here.
Keywords: focused ion; microscopy; myelin outfoldings; electron ... See more keywords
Dynamics of myelin deficits in the 5xFAD mouse model for Alzheimer's disease and the protective role of BDNF
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DOI: 10.1002/glia.24505
Abstract: Recent findings highlight myelin breakdown as a decisive early event in Alzheimer's Disease (AD) acting as aggravating factor of its progression. However, it is still unclear whether myelin loss is attributed to increased oligodendrocyte vulnerability,… read more here.
Keywords: alzheimer disease; disease; 5xfad mouse; role ... See more keywords
Myelin debris phagocytosis in demyelinating disease
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DOI: 10.1002/glia.24602
Abstract: Demyelinating diseases are often caused by a variety of triggers, including immune responses, viral infections, malnutrition, hypoxia, or genetic factors, all of which result in the loss of myelin in the nervous system. The accumulation… read more here.
Keywords: debris phagocytosis; myelin; myelin debris; phagocytosis demyelinating ... See more keywords
The role of ATP citrate lyase in myelin formation and maintenance
Sign Up to like & getrecommendations! Published in 2024 at "Glia"
DOI: 10.1002/glia.24620
Abstract: Formation of myelin by Schwann cells is tightly coupled to peripheral nervous system development and is important for neuronal function and long‐term maintenance. Perturbation of myelin causes a number of specific disorders that are among… read more here.
Keywords: myelin formation; myelin; formation maintenance; formation ... See more keywords