Effects of fluoride on synapse morphology and myelin damage in mouse hippocampus.
Sign Up to like & getrecommendations! Published in 2018 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2017.12.027
Abstract: To investigate the fluoride-induced neurotoxicity on mice hippocampus, healthy adult mice were exposed to 25, 50, and 100 mg NaF/L for 60 days. The results showed that medium and high fluoride administration induced ultrastructural alterations in… read more here.
Keywords: hippocampus; high fluoride; fluoride; myelin damage ... See more keywords
Vesicular glutamate release from central axons contributes to myelin damage
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-03427-1
Abstract: The axon myelin sheath is prone to injury associated with N-methyl-d-aspartate (NMDA)-type glutamate receptor activation but the source of glutamate in this context is unknown. Myelin damage results in permanent action potential loss and severe… read more here.
Keywords: glutamate release; myelin damage; vesicular glutamate; glutamate ... See more keywords
Blockage of MLKL prevents myelin damage in experimental diabetic neuropathy.
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2121552119
Abstract: SignificanceDiabetic neuropathy is a commonly occurring complication of diabetes that affects hundreds of millions of patients worldwide. Patients suffering from diabetic neuropathy experience abnormal sensations and have damage in their peripheral nerve axons as well… read more here.
Keywords: mlkl prevents; damage; prevents myelin; diabetic neuropathy ... See more keywords
Myelin heterogeneity for assessing normal appearing white matter myelin damage in multiple sclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuroimaging"
DOI: 10.1111/jon.13069
Abstract: Conventional MRI measures of multiple sclerosis (MS) disease severity, such as lesion volume and brain atrophy, do not provide information about microstructural tissue changes, which may be driving physical and cognitive progression. Myelin damage in… read more here.
Keywords: white matter; myelin; appearing white; multiple sclerosis ... See more keywords
Myelin damage and cortical atrophy in watershed regions in patients with moyamoya angiopathy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.982829
Abstract: Background Despite it being known that chronic ischemia results in myelin damage and gray matter atrophy, data regarding patients with moyamoya angiopathy is limited. We hypothesized that chronic ischemia in moyamoya angiopathy leads to myelin… read more here.
Keywords: watershed regions; moyamoya angiopathy; patients moyamoya; t1w t2w ... See more keywords